Meso-diaminopimelate D-dehydrogenase

BE0001593ProteinCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)ddh

Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. It is acted on by 2 drugs in DrugBank.

Gene name
ddh
UniProtKB entry
P04964Swiss-Prot
Residues / weight
320 residues · 35,199 Da
Also known as
1.4.1.16 · DAPDH

Resolves to

Protein
UniProtP04964UniProt nameDAPDH_CORGL
Gene
NCBI Gene1020564GenBank40493
Pharmacology
KEGGcgb:cg2900
Structure
PDB1DAPPDB1F06PDB2DAP
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Meso-diaminopimelate D-dehydrogenase, and which indications are they being tested in?

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