(S)-2-haloacid dehalogenase

BE0001613ProteinXanthobacter autotrophicusdhlB

Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids (PubMed:1744048). It is acted on by 2 drugs in DrugBank.

Gene name
dhlB
UniProtKB entry
Q60099Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
253 residues · 27,469 Da
Also known as
2-haloalkanoic acid dehalogenase · 3.8.1.2 · Halocarboxylic acid halidohydrolase · L-2-haloacid dehalogenase

Resolves to

Protein
UniProtQ60099UniProt nameHAD_XANAU
Gene
GenBank155350
Structure
PDB1AQ6PDB1QQ5PDB1QQ6
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on (S)-2-haloacid dehalogenase, how selective are they, and which programs against it are still in active trials?

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