2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

BE0001617ProteinThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)ispF

Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. It is acted on by 2 drugs in DrugBank.

Gene name
ispF
UniProtKB entry
Q8RQP5Swiss-Prot
Residues / weight
152 residues · 16,520 Da
Also known as
4.6.1.12 · MECDP-synthase

Resolves to

Protein
UniProtQ8RQP5UniProt nameISPF_THET8
Gene
NCBI Gene3169480GenBank19911566
Pharmacology
KEGGttj:TTHA1790
Structure
PDB1IV1PDB1IV2PDB1IV3
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, and which indications are they being tested in?

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