5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

BE0001620ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)metE

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. It is acted on by 2 drugs in DrugBank.

Gene name
metE
UniProtKB entry
Q9X112Swiss-Prot
Residues / weight
734 residues · 85,570 Da
Also known as
2.1.1.14 · Cobalamin-independent methionine synthase · Methionine synthase, vitamin-B12 independent isozyme

Resolves to

Protein
UniProtQ9X112UniProt nameMETE_THEMA
Gene
NCBI Gene898197GenBank4981844
Pharmacology
KEGGtma:TM1286
Structure
PDB1T7LPDB1XDJPDB1XPG
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, and which indications are they being tested in?

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