Purine nucleoside phosphorylase

Details

Name
Purine nucleoside phosphorylase
Kind
protein
Synonyms
  • 2.4.2.1
  • Inosine phosphorylase
  • Inosine-guanosine phosphorylase
  • PNP
Gene Name
punA
UniProtKB Entry
P81989Swiss-Prot
Organism
Cellulomonas sp.
NCBI Taxonomy ID
40001
Amino acid sequence
>lcl|BSEQ0011153|Purine nucleoside phosphorylase
TTTTPPSTPPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVA
EVPTHEIPGFSAPAVAGHLSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVR
TAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLR
ELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLG
VSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR
Number of residues
282
Molecular Weight
29020.585
Theoretical pI
5.48
GO Classification
Functions
purine-nucleoside phosphorylase activity
Processes
nucleoside metabolic process
General Function
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
Specific Function
purine-nucleoside phosphorylase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP81989
UniProtKB Entry NamePUNA_CELSP
PDB ID(s)1C3X, 1QE5
General References
  1. Tebbe J, Bzowska A, Wielgus-Kutrowska B, Schroder W, Kazimierczuk Z, Shugar D, Saenger W, Koellner G: Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs. J Mol Biol. 1999 Dec 17;294(5):1239-55. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
8-iodo-guanineexperimentalunknowntargetDetails