Purine nucleoside phosphorylase
Details
- Name
- Purine nucleoside phosphorylase
- Kind
- protein
- Synonyms
- 2.4.2.1
- Inosine phosphorylase
- Inosine-guanosine phosphorylase
- PNP
- Gene Name
- punA
- UniProtKB Entry
- P81989Swiss-Prot
- Organism
- Cellulomonas sp.
- NCBI Taxonomy ID
- 40001
- Amino acid sequence
>lcl|BSEQ0011153|Purine nucleoside phosphorylase TTTTPPSTPPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVA EVPTHEIPGFSAPAVAGHLSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVR TAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLR ELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLG VSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR
- Number of residues
- 282
- Molecular Weight
- 29020.585
- Theoretical pI
- 5.48
- GO Classification
- Functionspurine-nucleoside phosphorylase activityProcessesnucleoside metabolic process
- General Function
- The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
- Specific Function
- purine-nucleoside phosphorylase activity
- Pfam Domain Function
- PNP_UDP_1 (PF01048)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P81989 UniProtKB Entry Name PUNA_CELSP PDB ID(s) 1C3X, 1QE5 - General References
- Tebbe J, Bzowska A, Wielgus-Kutrowska B, Schroder W, Kazimierczuk Z, Shugar D, Saenger W, Koellner G: Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs. J Mol Biol. 1999 Dec 17;294(5):1239-55. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 8-iodo-guanine experimental unknown target Details