Uroporphyrinogen decarboxylase

BE0001629ProteinHumansUROD

Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:18004775, PubMed:21668429). It is acted on by 2 drugs in DrugBank.

Gene name
UROD
UniProtKB entry
P06132Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
367 residues · 40,787 Da
Also known as
4.1.1.37 · UPD · URO-D

Resolves to

Protein
UniProtP06132UniProt nameDCUP_HUMAN
Gene
HGNCHGNC:12591NCBI Gene7389GenBank340181GeneCardsUROD
Pharmacology
KEGGhsa:7389
Structure
PDB1JPHPDB1JPIPDB1JPK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Uroporphyrinogen decarboxylase, and which indications are they being tested in?

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