Pimeloyl-[acyl-carrier protein] methyl ester esterase

BE0001630ProteinEscherichia coli (strain K12)bioH

The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It is acted on by 2 drugs in DrugBank.

Gene name
bioH
UniProtKB entry
P13001Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
256 residues · 28,505 Da
Also known as
3.1.1.85 · bioB · Biotin synthesis protein BioH · Carboxylesterase BioH

Resolves to

Protein
UniProtP13001UniProt nameBIOH_ECOLI
Gene
NCBI Gene947916GenBank41068
Pharmacology
KEGGecj:JW3375
Structure
PDB1M33
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pimeloyl-[acyl-carrier protein] methyl ester esterase, how selective are they, and which programs against it are still in active trials?

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