6-deoxyerythronolide B hydroxylase

BE0001638ProteinSaccharopolyspora erythraea (strain NRRL 23338)eryF

Catalyzes the conversion of 6-deoxyerythronolide B (6-DEB) to erythronolide B (EB) by the insertion of an oxygen at the 6S position of 6-DEB. It is acted on by 3 drugs in DrugBank.

Gene name
eryF
UniProtKB entry
Q00441Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
404 residues · 45,099 Da
Also known as
1.14.13.188 · 1.14.15.35 · 6-DEB hydroxylase · CYP107A1 · CYPCVIIA1

Resolves to

Protein
UniProtQ00441UniProt nameCPXJ_SACEN
Gene
GenBank48942
Pharmacology
KEGGsen:SACE_0730
Structure
PDB1EGYPDB1EUPPDB1JIN
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 6-deoxyerythronolide B hydroxylase, and which indications are they being tested in?

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