Chitinase A

Details

Name
Chitinase A
Kind
protein
Synonyms
  • 3.2.1.14
Gene Name
chiA
UniProtKB Entry
P07254Swiss-Prot
Organism
Serratia marcescens
NCBI Taxonomy ID
615
Amino acid sequence
>lcl|BSEQ0016505|Chitinase A
MRKFNKPLLALLIGSTLCSAAQAAAPGKPTIAWGNTKFAIVEVDQAATAYNNLVKVKNAA
DVSVSWNLWNGDAGTTAKILLNGKEAWSGPSTGSSGTANFKVNKGGRYQMQVALCNADGC
TASDATEIVVADTDGSHLAPLKEPLLEKNKPYKQNSGKVVGSYFVEWGVYGRNFTVDKIP
AQNLTHLLYGFIPICGGNGINDSLKEIEGSFQALQRSCQGREDFKVSIHDPFAALQKAQK
GVTAWDDPYKGNFGQLMALKQAHPDLKILPSIGGWTLSDPFFFMGDKVKRDRFVGSVKEF
LQTWKFFDGVDIDWEFPGGKGANPNLGSPQDGETYVLLMKELRAMLDQLSAETGRKYELT
SAISAGKDKIDKVAYNVAQNSMDHIFLMSYDFYGPFDLKNLGHQTALNAPAWKPDTAYTT
VNGVNALLAQGVKPGKVVVGTAMYGRGWTGVNGYQNNIPFTGTATGPVKGTWKNGIVDYR
QIAGQFMSGEWQYTYDATAEAPYVFKPSTGDLITFDDARSVQAKGKYVLDKQLGGLFSWE
IDADNGDILNSMNASLGNSAGVQ
Number of residues
563
Molecular Weight
60978.56
Theoretical pI
7.48
GO Classification
Functions
chitinase activity
Processes
chitin catabolic process / polysaccharide catabolic process
General Function
Chitinase activity
Specific Function
Not Available
Pfam Domain Function
Signal Regions
1-23
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0003270|1689 bp
ATGCGCAAATTTAATAAACCGCTGTTGGCGCTGTTGATCGGCAGCACGCTGTGTTCCGCG
GCGCAGGCCGCCGCGCCGGGCAAGCCGACCATCGCCTGGGGCAACACCAAGTTCGCCATC
GTTGAAGTTGACCAGGCGGCTACCGCTTATAATAATTTGGTGAAGGTAAAAAATGCCGCC
GATGTTTCCGTCTCCTGGAATTTATGGAATGGCGACGCGGGCACGACGGCCAAGATTTTA
TTAAATGGTAAAGAGGCGTGGAGTGGTCCTTCAACCGGATCTTCCGGTACGGCGAATTTT
AAAGTGAATAAAGGCGGCCGTTATCAAATGCAGGTGGCATTGTGCAATGCCGACGGCTGC
ACCGCCAGTGACGCCACCGAAATTGTGGTGGCCGACACCGACGGCAGCCATTTGGCGCCG
TTGAAAGAGCCGCTGCTGGAAAAGAATAAACCGTATAAACAGAACTCCGGCAAAGTGGTC
GGTTCTTATTTCGTCGAGTGGGGCGTTTACGGGCGCAATTTCACCGTCGACAAGATCCCG
GCGCAAAACCTGACCCACCTGCTGTACGGCTTTATCCCGATCTGCGGCGGCAATGGCATC
AACGACAGCCTGAAAGAGATTGAAGGCAGCTTCCAGGCGTTACAGCGCTCCTGCCAGGGC
CGCGAGGACTTCAAAGTCTCGATCCACGATCCGTTCGCCGCGCTGCAAAAAGCGCAGAAG
GGCGTGACCGCCTGGGATGACCCCTACAAGGGCAACTTCGGCCAGCTGATGGCGCTGAAG
CAGGCGCATCCTGACCTGAAAATCCTGCCGTCGATCGGCGGCTGGACGCTGTCCGACCCG
TTCTTCTTCATGGGCGACAAGGTGAAGCGCGATCGCTTCGTCGGTTCGGTGAAAGAGTTC
CTGCAGACCTGGAAGTTCTTCGACGGCGTGGATATCGACTGGGAGTTCCCGGGCGGCAAA
GGCGCCAACCCTAACCTGGGCAGCCCGCAAGACGGGGAAACCTATGTGTTGCTGATGAAG
GAGCTGCGGGCGATGCTGGATCAGCTGTCGGCGGAAACCGGCCGCAAGTATGAGCTGACC
TCCGCCATCAGCGCCGGTAAGGACAAGATCGACAAGGTGGCTTACAACGTTGCGCAGAAC
TCGATGGATCACATCTTCCTGATGAGCTACGACTTCTATGGCGCCTTCGATCTGAAGAAC
CTGGGGCATCAGACCGCGCTGAATGCGCGGCCTGGAAGCCGACACCGCTTACACCACGGT
GAACGGCGTCAATGCGCTGCTGGCCAGGGCGTCAAGCCGGGGAAAGTCGTCGTCGGCACC
GCCATGTATGGCCGCGGCTGGACCGGGGTGAACGGCTACCAGAACAACATTCCGTTCACC
GGTACCGCCACTGGGCCGGTTAAAGGCACCTGGAAGAACGGCATCGTGGACTACCGCCAA
ATCGCCGGCCAGTTCATGAGCGGCGAGTGGCAGTATACCTACGACGCCACGGCGGAAGCG
CCTTACGTGTTCAAACCTTCCACCGGCGATCTGATCACCTTCGACGATGCCCGCTCGGTG
CAGGCCAAAGGCAAGTACGTGCTGGATAAGCAGCTGGGCGGCCTGTTCTCCTGGGAGATC
GACGCGGATAACGGCGATATTCTCAACAGCATGAACGCCAGCCTGGGCAACAGCGCCGGC
GTTCAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP07254
UniProtKB Entry NameCHIA_SERMA
GenBank Protein ID152818
GenBank Gene IDL01455
PDB ID(s)1CTN, 1EHN, 1EIB, 1FFQ, 1FFR, 1K9T, 1NH6, 1RD6, 1X6L, 1X6N, 2WK2, 2WLY, 2WLZ, 2WM0
General References
  1. Jones JD, Grady KL, Suslow TV, Bedbrook JR: Isolation and characterization of genes encoding two chitinase enzymes from Serratia marcescens. EMBO J. 1986 Mar;5(3):467-73. [Article]
  2. Brurberg MB, Eijsink VG, Nes IF: Characterization of a chitinase gene (chiA) from Serratia marcescens BJL200 and one-step purification of the gene product. FEMS Microbiol Lett. 1994 Dec 15;124(3):399-404. [Article]
  3. Perrakis A, Tews I, Dauter Z, Oppenheim AB, Chet I, Wilson KS, Vorgias CE: Crystal structure of a bacterial chitinase at 2.3 A resolution. Structure. 1994 Dec 15;2(12):1169-80. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2-acetylamino-2-deoxy-b-D-allopyranoseexperimentalunknowntargetDetails
AllosamizolineexperimentalunknowntargetDetails
AllosamidinexperimentalunknowntargetDetails