N-acetylneuraminate lyase

BE0001650ProteinShigella flexnerinanA

Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. It is acted on by 1 drug in DrugBank.

Gene name
nanA
UniProtKB entry
P0A6L6Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
297 residues · 32,593 Da
Also known as
4.1.3.3 · N-acetylneuraminate pyruvate-lyase · N-acetylneuraminic acid aldolase · NAL · NALase

Resolves to

Protein
UniProtP0A6L6UniProt nameNANA_SHIFL
Gene
NCBI Gene1027061GenBank24053696
Pharmacology
KEGGsfl:SF3261
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on N-acetylneuraminate lyase, and which indications are they being tested in?

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