DNA-3-methyladenine glycosylase 1

BE0001657ProteinEscherichia coli (strain K12)tag

Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions. It is acted on by 1 drug in DrugBank.

Gene name
tag
UniProtKB entry
P05100Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
187 residues · 21,100 Da
Also known as
3-methyladenine-DNA glycosylase I, constitutive · 3.2.2.20 · DNA-3-methyladenine glycosidase I · DNA-3-methyladenine glycosylase I · TAG I

Resolves to

Protein
UniProtP05100UniProt name3MG1_ECOLI
Gene
NCBI Gene947137GenBank147920
Pharmacology
KEGGecj:JW3518
Structure
PDB1LMZPDB1NKUPDB1P7M
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA-3-methyladenine glycosylase 1, and which indications are they being tested in?

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