2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

BE0001661ProteinEscherichia coli (strain K12)ispD

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). It is acted on by 3 drugs in DrugBank.

Gene name
ispD
UniProtKB entry
Q46893Swiss-Prot
Residues / weight
236 residues · 25,737 Da
Also known as
2.7.7.60 · 4-diphosphocytidyl-2C-methyl-D-erythritol synthase · CDP-ME synthase · MCT · MEP cytidylyltransferase

Resolves to

Protein
UniProtQ46893UniProt nameISPD_ECOLI
Gene
NCBI Gene948269GenBank7239372
Pharmacology
KEGGecj:JW2717
Structure
PDB1H3MPDB1I52PDB1INI
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, and which indications are they being tested in?

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