4-alpha-glucanotransferase

Details

Name
4-alpha-glucanotransferase
Kind
protein
Synonyms
  • 2.4.1.25
  • Amylomaltase
  • D-enzyme
  • Disproportionating enzyme
Gene Name
mgtA
UniProtKB Entry
P80099Swiss-Prot
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
NCBI Taxonomy ID
243274
Amino acid sequence
>lcl|BSEQ0011186|4-alpha-glucanotransferase
MIGYQIYVRSFRDGNLDGVGDFRGLKNAVSYLKELGIDFVWLMPVFSSISFHGYDVVDFY
SFKAEYGSEREFKEMIEAFHDSGIKVVLDLPIHHTGFLHTWFQKALKGDPHYRDYYVWAN
KETDLDERREWDGEKIWHPLEDGRFYRGLFGPFSPDLNYDNPQVFDEMKRLVLHLLDMGV
DGFRFDAAKHMRDTIEQNVRFWKYFLSDLKGIFLAEIWAEARMVDEHGRIFGYMLNFDTS
HCIKEAVWKENTRVLIESIERAVIGKDYLPVNFTSNHDMSRLASFEGGFSKEKIKLSISI
LFTLPGVPLVFYGDELGMKGVYQKPNTEVVLDPFPWNESMCVEGQTFWKWPAYNGPFSGI
SVEYQKRDPDSILSHTLGWTRFRKENQWIDRAKLEFLCKEDKFLVYRLYDDQHSLKVFHN
LSGEEVVFEGVKMKPYKTEVV
Number of residues
441
Molecular Weight
51842.69
Theoretical pI
5.74
GO Classification
Functions
4-alpha-glucanotransferase activity / metal ion binding
Components
cytoplasm
General Function
Not Available
Specific Function
4-alpha-glucanotransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011187|4-alpha-glucanotransferase (mgtA)
ATGATAGGCTATCAGATCTACGTGAGATCTTTCAGGGATGGAAACCTCGACGGTGTGGGA
GATTTCAGGGGATTGAAAAACGCTGTTTCCTACCTGAAAGAACTGGGGATTGACTTTGTC
TGGCTCATGCCTGTTTTTTCCTCCATATCTTTTCACGGGTACGACGTGGTGGATTTTTAT
TCTTTCAAAGCTGAGTACGGTAGTGAGAGAGAGTTCAAAGAGATGATCGAGGCATTCCAC
GACAGCGGAATAAAAGTCGTTCTTGACCTTCCCATCCATCACACAGGCTTTCTCCACACG
TGGTTCCAGAAGGCGCTGAAAGGAGATCCACACTACAGAGATTACTACGTATGGGCAAAC
AAAGAGACGGATCTGGACGAAAGAAGAGAGTGGGATGGAGAAAAGATCTGGCATCCCCTG
GAAGATGGGAGGTTCTACAGAGGGCTCTTTGGACCTTTCTCACCCGACTTGAACTACGAC
AACCCGCAGGTATTCGATGAAATGAAAAGACTGGTTCTCCACCTTCTCGATATGGGAGTG
GATGGTTTCAGGTTCGATGCAGCAAAGCACATGAGAGATACGATCGAACAGAATGTTCGC
TTCTGGAAGTACTTTCTTTCCGATTTGAAGGGCATCTTCCTCGCAGAGATATGGGCAGAG
GCCAGAATGGTGGATGAACACGGCAGAATATTTGGCTACATGCTCAACTTTGACACATCC
CACTGTATAAAGGAAGCTGTATGGAAAGAGAACACAAGAGTTCTGATAGAGTCGATCGAA
AGGGCCGTTATCGGCAAAGACTACCTCCCGGTGAATTTTACTTCGAATCACGACATGTCG
AGGCTTGCAAGCTTTGAAGGAGGCTTCAGCAAAGAAAAGATCAAACTTTCGATTTCCATT
CTTTTCACTCTCCCGGGAGTTCCTCTCGTGTTCTATGGGGATGAGCTTGGAATGAAGGGA
GTTTACCAGAAACCGAACACAGAAGTCGTCCTGGATCCGTTCCCGTGGAACGAGAGTATG
TGCGTTGAGGGACAGACCTTCTGGAAGTGGCCCGCGTACAACGGGCCTTTCTCTGGTATC
TCCGTAGAATACCAGAAGAGAGATCCCGATTCGATTCTTTCACACACTCTGGGATGGACG
AGATTCAGAAAGGAAAACCAGTGGATCGATCGGGCAAAGCTCGAATTTTTGTGTAAAGAG
GACAAGTTTCTTGTGTACAGACTCTACGATGATCAGCATTCTTTGAAGGTGTTTCACAAT
CTTTCAGGGGAAGAGGTTGTCTTTGAGGGAGTTAAAATGAAGCCTTACAAAACGGAGGTG
GTTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP80099
UniProtKB Entry NameMGTA_THEMA
GenBank Protein ID4980866
GenBank Gene IDAE000512
PDB ID(s)1LWH, 1LWJ
KEGG IDtma:TM0364
NCBI Gene ID897323
General References
  1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
  2. Liebl W, Feil R, Gabelsberger J, Kellermann J, Schleifer KH: Purification and characterization of a novel thermostable 4-alpha-glucanotransferase of Thermotoga maritima cloned in Escherichia coli. Eur J Biochem. 1992 Jul 1;207(1):81-8. [Article]
  3. Roujeinikova A, Raasch C, Sedelnikova S, Liebl W, Rice DW: Crystal structure of Thermotoga maritima 4-alpha-glucanotransferase and its acarbose complex: implications for substrate specificity and catalysis. J Mol Biol. 2002 Aug 2;321(1):149-62. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Modified Acarbose PentasaccharideexperimentalunknowntargetDetails