DNA polymerase I, thermostable

BE0001665ProteinThermus aquaticuspolA

In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). It is acted on by 3 drugs in DrugBank.

Gene name
polA
UniProtKB entry
P19821Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
832 residues · 93,909 Da
Also known as
2.7.7.7 · pol1 · Taq polymerase 1

Resolves to

Protein
UniProtP19821UniProt nameDPO1_THEAQ
Gene
GenBank155129
Structure
PDB1BGXPDB1JXEPDB1KTQ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase I, thermostable, how selective are they, and which programs against it are still in active trials?

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