Polyamine aminopropyltransferase

BE0001674ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)speE

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. It is acted on by 1 drug in DrugBank.

Gene name
speE
UniProtKB entry
Q9WZC2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
296 residues · 34,142 Da
Also known as
PAPT · Putrescine aminopropyltransferase · SPDS · SPDSY · Spermidine synthase

Resolves to

Protein
UniProtQ9WZC2UniProt nameSPEE_THEMA
Gene
NCBI Gene897762GenBank4981177
Pharmacology
KEGGtma:TM0654
Structure
PDB1INLPDB1JQ3
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Polyamine aminopropyltransferase, and which indications are they being tested in?

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