Ribose-phosphate pyrophosphokinase

BE0001675ProteinBacillus subtilis (strain 168)prs

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). It is acted on by 2 drugs in DrugBank.

Gene name
prs
UniProtKB entry
P14193Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
317 residues · 34,868 Da
Also known as
2.7.6.1 · 5-phospho-D-ribosyl alpha-1-diphosphate · 5-phospho-D-ribosyl alpha-1-diphosphate synthase · P-Rib-PP synthase · Phosphoribosyl diphosphate synthase

Resolves to

Protein
UniProtP14193UniProt nameKPRS_BACSU
Gene
NCBI Gene11237812GenBank40218
Pharmacology
KEGGbsu:BSU00510
Structure
PDB1DKRPDB1DKUPDB1IBS
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ribose-phosphate pyrophosphokinase, and which indications are they being tested in?

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