Orotidine 5'-phosphate decarboxylase

BE0001677ProteinEscherichia coli (strain K12)pyrF

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). It is acted on by 3 drugs in DrugBank.

Gene name
pyrF
UniProtKB entry
P08244Swiss-Prot
Residues / weight
245 residues · 26,350 Da
Also known as
4.1.1.23 · OMP decarboxylase · OMPDCase · OMPdecase

Resolves to

Protein
UniProtP08244UniProt namePYRF_ECOLI
Gene
NCBI Gene947121GenBank147475
Pharmacology
KEGGecj:JW1273
Structure
PDB1EIXPDB1JJKPDB1L2U
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Orotidine 5'-phosphate decarboxylase, and which indications are they being tested in?

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