3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
Details
- Name
- 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
- Kind
- protein
- Synonyms
- 1.1.1.53
- Gene Name
- fabG3
- UniProtKB Entry
- P9WGT1Swiss-Prot
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- NCBI Taxonomy ID
- 83332
- Amino acid sequence
>lcl|BSEQ0051245|3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVHL DVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGI RAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNS IHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVA GLAHNDFGAVEVSSQPEWVT
- Number of residues
- 260
- Molecular Weight
- 27029.535
- Theoretical pI
- Not Available
- GO Classification
- Functionsandrostan-3-alpha,17-beta-diol dehydrogenase activityProcessesC21-steroid hormone metabolic process / steroid metabolic processComponentsplasma membrane
- General Function
- Probably involved in steroid metabolism. Catalyzes the oxidation of androsterone (3alpha-hydroxy-5alpha-androstan-17-one) and 20beta-hydroxyprogesterone (4-pregnen-20beta-ol-3-one), and the reduction of progesterone (4-pregnen-3,20-dione). Shows a preference for NADH. Has no detectable activity for oxidation of L-3-hydroxybutyric acid and only an insignificant activity for reduction of acetoacetyl-CoA.
- Specific Function
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- Pfam Domain Function
- Not Available
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051246|3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase (fabG3) ATGTCTGGACGGTTGATAGGAAAGGTCGCACTTGTCAGCGGCGGGGCGCGCGGTATGGGT GCATCCCATGTGCGGGCGATGGTGGCCGAAGGCGCAAAGGTTGTGTTCGGCGACATCCTC GACGAGGAGGGCAAGGCGGTGGCCGCCGAACTGGCCGATGCGGCCCGCTACGTCCATCTC GACGTTACCCAACCCGCGCAATGGACGGCTGCGGTGGACACCGCGGTCACCGCATTCGGT GGCCTGCACGTGCTGGTCAACAACGCCGGCATTCTCAACATCGGGACGATCGAGGACTAC GCCCTCACCGAATGGCAGCGCATCCTCGATGTCAACCTGACCGGAGTCTTCCTGGGCATC CGCGCTGTCGTCAAGCCAATGAAAGAGGCTGGTCGCGGCTCCATCATCAACATTTCGTCG ATCGAGGGGCTGGCCGGCACGGTTGCTTGTCATGGCTATACCGCCACCAAGTTCGCCGTG CGGGGGCTGACCAAGTCCACCGCTCTCGAGTTGGGGCCCAGCGGAATTCGAGTCAACTCG ATTCACCCTGGGTTGGTCAAGACGCCGATGACTGACTGGGTCCCCGAAGACATCTTCCAG ACCGCGCTGGGCCGCGCGGCCGAACCCGTGGAAGTGTCCAACCTCGTCGTCTACCTGGCC AGCGATGAGTCGAGCTATTCCACCGGCGCGGAATTTGTGGTCGACGGCGGGACCGTAGCT GGCCTGGCACACAACGACTTCGGTGCCGTCGAGGTGTCCTCGCAGCCGGAATGGGTGACG TAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WGT1 UniProtKB Entry Name HSD_MYCTU PDB ID(s) 1NFF, 1NFQ, 1NFR KEGG ID mtu:Rv2002 NCBI Gene ID 888857 - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Yang JK, Park MS, Waldo GS, Suh SW: Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):455-60. Epub 2003 Jan 10. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Aetiocholanolone experimental unknown target Details