Bis(5'-adenosyl)-triphosphatase

BE0001687ProteinHumansFHIT

Possesses dinucleoside triphosphate hydrolase activity (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9543008, PubMed:9576908). It is acted on by 3 drugs in DrugBank.

Gene name
FHIT
UniProtKB entry
P49789Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
147 residues · 16,858 Da
Also known as
3.6.1.29 · Adenosine 5'-monophosphoramidase FHIT · Adenylylsulfatase · Adenylylsulfate-ammonia adenylyltransferase · AP3A hydrolase

Resolves to

Protein
UniProtP49789UniProt nameFHIT_HUMAN
Gene
HGNCHGNC:3701NCBI Gene2272GenBank1203836GeneCardsFHIT
Pharmacology
KEGGhsa:2272
Structure
PDB1FHIPDB1FITPDB2FHI
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bis(5'-adenosyl)-triphosphatase, how selective are they, and which programs against it are still in active trials?

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