Diacylglycerol acyltransferase/mycolyltransferase Ag85C

BE0001688ProteinMycobacterium tuberculosisfbpC

The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). It is acted on by 2 drugs in DrugBank.

Gene name
fbpC
UniProtKB entry
P9WQN9Swiss-Prot
Cellular location
Secreted
Residues / weight
340 residues · 36,771 Da
Also known as
2.3.1.122 · 85C · Acyl-CoA:diacylglycerol acyltransferase · Ag85C · Antigen 85 complex C

Resolves to

Protein
UniProtP9WQN9UniProt nameA85C_MYCTU
Gene
NCBI Gene886885
Pharmacology
KEGGmtu:Rv0129c
Structure
PDB1DQYPDB1DQZPDB1VA5
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Diacylglycerol acyltransferase/mycolyltransferase Ag85C, and which indications are they being tested in?

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