Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

BE0001689ProteinMycobacterium tuberculosisrraA

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. It is acted on by 1 drug in DrugBank.

Gene name
rraA
UniProtKB entry
P9WGY3Swiss-Prot
Residues / weight
157 residues · 16,235 Da
Also known as
4.1.3.17 · HMG aldolase · OAA decarboxylase · Oxaloacetate decarboxylase · Regulator of ribonuclease activity homolog

Resolves to

Protein
UniProtP9WGY3UniProt nameRRAAH_MYCTU
Gene
NCBI Gene886181
Pharmacology
KEGGmtu:Rv3853
Structure
PDB1NXJ
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, and which indications are they being tested in?

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