Nicotinate-nucleotide adenylyltransferase

Details

Name
Nicotinate-nucleotide adenylyltransferase
Kind
protein
Synonyms
  • 2.7.7.18
  • Deamido-NAD(+) diphosphorylase
  • Deamido-NAD(+) pyrophosphorylase
  • NaMN adenylyltransferase
  • Nicotinate mononucleotide adenylyltransferase
  • yqeJ
Gene Name
nadD
UniProtKB Entry
P54455Swiss-Prot
Organism
Bacillus subtilis (strain 168)
NCBI Taxonomy ID
224308
Amino acid sequence
>lcl|BSEQ0016528|Nicotinate-nucleotide adenylyltransferase
MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPHKQNEDYTDSFHRVEML
KLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLFFIIGADMIEYLPKWYKLD
ELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIRERFKSKKPTDYLIPDKVKKY
VEENGLYES
Number of residues
189
Molecular Weight
22156.34
Theoretical pI
5.11
GO Classification
Functions
ATP binding / nicotinate-nucleotide adenylyltransferase activity
Processes
NAD biosynthetic process
General Function
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016529|Nicotinate-nucleotide adenylyltransferase (nadD)
ATGAAGAAAATCGGAATTTTCGGAGGCACGTTTGACCCTCCGCATAATGGTCACCTCTTA
ATGGCGAATGAGGTGCTGTACCAGGCGGGGCTTGATGAAATTTGGTTTATGCCTAATCAA
ATTCCGCCGCATAAACAGAACGAAGACTATACCGACAGCTTTCATCGCGTGGAAATGCTA
AAGCTTGCAATTCAATCTAATCCGTCCTTTAAGCTGGAGCTTGTTGAAATGGAAAGAGAA
GGGCCATCATATACCTTTGATACCGTTTCTTTACTGAAGCAGCGTTATCCAAATGATCAG
CTGTTCTTTATTATCGGCGCTGATATGATTGAATATTTGCCGAAATGGTATAAGCTGGAC
GAGCTGCTGAACCTCATTCAATTTATTGGAGTAAAGCGCCCCGGTTTTCATGTTGAAACC
CCTTATCCGCTTCTCTTTGCAGACGTTCCGGAATTTGAGGTATCATCAACTATGATAAGG
GAACGGTTTAAAAGCAAGAAGCCCACTGACTACTTAATCCCTGATAAAGTGAAGAAGTAT
GTAGAGGAGAATGGTTTATATGAATCGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP54455
UniProtKB Entry NameNADD_BACSU
GenBank Protein ID1303791
GenBank Gene IDD84432
PDB ID(s)1KAM, 1KAQ
KEGG IDbsu:BSU25640
NCBI Gene ID937818
General References
  1. Mizuno M, Masuda S, Takemaru K, Hosono S, Sato T, Takeuchi M, Kobayashi Y: Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes. Microbiology. 1996 Nov;142 ( Pt 11):3103-11. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Olland AM, Underwood KW, Czerwinski RM, Lo MC, Aulabaugh A, Bard J, Stahl ML, Somers WS, Sullivan FX, Chopra R: Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase. J Biol Chem. 2002 Feb 1;277(5):3698-707. Epub 2001 Nov 9. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Deamido-Nad+experimentalunknowntargetDetails