3-isopropylmalate dehydrogenase

BE0001699ProteinThiobacillus ferrooxidansleuB

Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. It is acted on by 1 drug in DrugBank.

Gene name
leuB
UniProtKB entry
Q56268Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
358 residues · 38,462 Da
Also known as
1.1.1.85 · 3-IPM-DH · Beta-IPM dehydrogenase · IMDH

Resolves to

Protein
UniProtQ56268UniProt nameLEU3_ACIFR
Gene
GenBank414355
Structure
PDB1A05
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-isopropylmalate dehydrogenase, and which indications are they being tested in?

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