Deoxycytidylate deaminase

Details

Name
Deoxycytidylate deaminase
Kind
protein
Synonyms
  • 3.5.4.12
  • dCD
  • dCMP deaminase
Gene Name
CD
UniProtKB Entry
P16006Swiss-Prot
Organism
Enterobacteria phage T4
NCBI Taxonomy ID
10665
Amino acid sequence
>lcl|BSEQ0011217|Deoxycytidylate deaminase
MKASTVLQIAYLVSQESKCCSWKVGAVIEKNGRIISTGYNGSPAGGVNCCDYAAEQGWLL
NKPKHAIIQGHKPECVSFGSTDRFVLAKEHRSAHSEWSSKNEIHAELNAILFAARNGSSI
EGATMYVTLSPCPDCAKAIAQSGIKKLVYCETYDKNKPGWDDILRNAGIEVFNVPKKNLN
KLNWENINEFCGE
Number of residues
193
Molecular Weight
21197.94
Theoretical pI
7.94
GO Classification
Functions
dCMP deaminase activity / zinc ion binding
Processes
nucleotide biosynthetic process / pyrimidine nucleotide metabolic process
General Function
Supplies the nucleotide substrate for thymidylate synthetase.
Specific Function
dCMP deaminase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011218|Deoxycytidylate deaminase (CD)
ATGAAAGCGAGTACAGTACTTCAAATTGCATATTTAGTATCGCAGGAATCAAAATGTTGC
TCCTGGAAGGTAGGAGCAGTAATTGAAAAGAATGGACGTATTATTTCTACTGGGTATAAT
GGTTCACCCGCAGGGGGTGTGAACTGTTGTGATTATGCTGCTGAGCAAGGATGGTTGTTG
AATAAGCCTAAACATGCTATCATTCAAGGTCATAAGCCTGAATGCGTATCATTTGGTTCA
ACTGATCGTTTTGTTTTGGCGAAAGAACATCGTAGTGCTCACTCGGAATGGTCATCTAAA
AATGAAATTCATGCTGAACTAAATGCAATTTTGTTTGCTGCACGAAATGGTTCTTCTATT
GAAGGTGCTACTATGTATGTAACACTTTCTCCTTGTCCAGATTGCGCAAAAGCGATAGCT
CAATCTGGTATTAAAAAGCTGGTTTATTGTGAAACATACGACAAAAATAAACCCGGTTGG
GATGATATTCTGCGAAATGCAGGTATTGAAGTGTTTAATGTTCCTAAGAAAAACTTGAAT
AAGTTAAACTGGGAAAATATCAACGAATTCTGTGGTGAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP16006
UniProtKB Entry NameDCTD_BPT4
GenBank Protein ID215838
GenBank Gene IDJ05172
PDB ID(s)1VQ2
KEGG IDvg:1258669
NCBI Gene ID1258669
General References
  1. Maley GF, Duceman BW, Wang AM, Martinez J, Maley F: Cloning, sequence analysis, and expression of the bacteriophage T4 cd gene. J Biol Chem. 1990 Jan 5;265(1):47-51. [Article]
  2. Miller ES, Kutter E, Mosig G, Arisaka F, Kunisawa T, Ruger W: Bacteriophage T4 genome. Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents. [Article]
  3. Moore JT, Silversmith RE, Maley GF, Maley F: T4-phage deoxycytidylate deaminase is a metalloprotein containing two zinc atoms per subunit. J Biol Chem. 1993 Feb 5;268(4):2288-91. [Article]
  4. Almog R, Maley F, Maley GF, Maccoll R, Van Roey P: Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase. Biochemistry. 2004 Nov 2;43(43):13715-23. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
3,4-Dihydro-2'-deoxyuridine-5'-monophosphateexperimentalunknowntargetDetails