3-deoxy-manno-octulosonate cytidylyltransferase

BE0001714ProteinHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)kdsB

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. It is acted on by 1 drug in DrugBank.

Gene name
kdsB
UniProtKB entry
P44490Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
254 residues · 28,255 Da
Also known as
2.7.7.38 · CKS · CMP-2-keto-3-deoxyoctulosonic acid synthase · CMP-KDO synthase

Resolves to

Protein
UniProtP44490UniProt nameKDSB_HAEIN
Gene
NCBI Gene950957GenBank1573006
Pharmacology
KEGGhin:HI0058
Structure
PDB1VH3PDB1VICPDB3DUV
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-deoxy-manno-octulosonate cytidylyltransferase, and which indications are they being tested in?

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