3-deoxy-manno-octulosonate cytidylyltransferase

Details

Name
3-deoxy-manno-octulosonate cytidylyltransferase
Kind
protein
Synonyms
  • 2.7.7.38
  • CKS
  • CMP-2-keto-3-deoxyoctulosonic acid synthase
  • CMP-KDO synthase
Gene Name
kdsB
UniProtKB Entry
P44490Swiss-Prot
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
NCBI Taxonomy ID
71421
Amino acid sequence
>lcl|BSEQ0019164|3-deoxy-manno-octulosonate cytidylyltransferase
MSFTVIIPARFASSRLPGKPLADIKGKPMIQHVFEKALQSGASRVIIATDNENVADVAKS
FGAEVCMTSVNHNSGTERLAEVVEKLAIPDNEIIVNIQGDEPLIPPVIVRQVADNLAKFN
VNMASLAVKIHDAEELFNPNAVKVLTDKDGYVLYFSRSVIPYDRDQFMNLQDVQKVQLSD
AYLRHIGIYAYRAGFIKQYVQWAPTQLENLEKLEQLRVLYNGERIHVELAKEVPAVGVDT
AEDLEKVRAILAAN
Number of residues
254
Molecular Weight
28255.205
Theoretical pI
5.39
GO Classification
Functions
3-deoxy-manno-octulosonate cytidylyltransferase activity
Processes
CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process / keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
Components
cytoplasm
General Function
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Specific Function
3-deoxy-manno-octulosonate cytidylyltransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019165|3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
ATGTCATTTACCGTGATTATCCCCGCTCGTTTTGCATCAAGTCGTTTGCCAGGAAAACCT
CTTGCTGATATTAAAGGTAAGCCAATGATTCAACATGTATTTGAGAAAGCACTGCAGTCT
GGGGCGAGCCGAGTGATTATTGCCACCGATAATGAAAATGTGGCTGATGTTGCCAAAAGT
TTTGGTGCTGAAGTCTGTATGACTTCGGTTAATCATAATTCTGGTACAGAACGTTTAGCA
GAAGTTGTAGAAAAATTAGCTATTCCTGACAATGAAATCATTGTCAATATTCAAGGCGAT
GAGCCTTTGATTCCTCCCGTTATCGTGCGACAAGTGGCAGATAATTTAGCAAAATTTAAT
GTCAATATGGCAAGCCTTGCGGTAAAAATTCACGATGCTGAGGAATTATTTAATCCAAAT
GCAGTGAAAGTATTAACAGATAAAGATGGCTATGTGCTGTATTTTTCCCGTTCGGTTATT
CCTTATGATCGTGATCAGTTTATGAATTTGCAGGATGTTCAGAAAGTACAGCTTTCTGAC
GCTTACTTACGTCATATTGGCATTTACGCATATCGTGCGGGTTTCATAAAACAATATGTG
CAATGGGCACCGACTCAACTTGAAAATCTAGAAAAACTTGAGCAGCTTCGTGTGTTATAT
AACGGCGAACGTATTCACGTAGAACTTGCGAAAGAAGTGCCTGCAGTGGGGGTGGATACC
GCCGAAGATTTGGAAAAAGTGCGGGCAATTTTAGCGGCGAATTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP44490
UniProtKB Entry NameKDSB_HAEIN
GenBank Protein ID1573006
GenBank Gene IDL42023
PDB ID(s)1VH3, 1VIC, 3DUV
KEGG IDhin:HI0058
NCBI Gene ID950957
General References
  1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Cmp-2-Keto-3-Deoxy-Octulosonic AcidexperimentalunknowntargetDetails