Phospho-2-dehydro-3-deoxyheptonate aldolase

BE0001721ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)aroF

Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). It is acted on by 2 drugs in DrugBank.

Gene name
aroF
UniProtKB entry
Q9WYH8Swiss-Prot
Residues / weight
338 residues · 37,378 Da
Also known as
2.5.1.54 · 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase · DAHP synthase · Phospho-2-keto-3-deoxyheptonate aldolase

Resolves to

Protein
UniProtQ9WYH8UniProt nameAROF_THEMA
Gene
NCBI Gene897299GenBank4980844
Pharmacology
KEGGtma:TM0343
Structure
PDB1RZMPDB1VR6PDB3PG8
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phospho-2-dehydro-3-deoxyheptonate aldolase, and which indications are they being tested in?

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