5,6,7,8-tetrahydromethanopterin hydro-lyase

Details

Name
5,6,7,8-tetrahydromethanopterin hydro-lyase
Kind
protein
Synonyms
  • 4.2.1.147
  • Fae
  • Formaldehyde-activating enzyme
Gene Name
fae
UniProtKB Entry
Q9FA38Swiss-Prot
Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
NCBI Taxonomy ID
272630
Amino acid sequence
>lcl|BSEQ0011228|5,6,7,8-tetrahydromethanopterin hydro-lyase
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAMAVQDAVAEGIIPADEADDLYVLVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKASVVTEQRKSATHPFAANA
Number of residues
170
Molecular Weight
18090.515
Theoretical pI
5.99
GO Classification
Functions
carbon-nitrogen lyase activity
Processes
carbohydrate biosynthetic process / formaldehyde catabolic process / one-carbon metabolic process / response to toxic substance
Components
cytoplasm
General Function
Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium.
Specific Function
carbon-nitrogen lyase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011229|5,6,7,8-tetrahydromethanopterin hydro-lyase (fae)
ATGGCAAAAATCACCAAGGTTCAGGTCGGCGAGGCCCTCGTCGGCGATGGCAACGAAGTC
GCTCACATCGACCTCATCATCGGACCGCGCGGTTCGCCGGCCGAGACGGCCTTCTGCAAC
GGTCTGGTCAACAACAAGCACGGCTTCACCAGCCTGCTCGCCGTGATCGCGCCGAACCTG
CCGTGCAAGCCGAACACGCTGATGTTCAACAAGGTCACCATCAACGACGCCCGTCAGGCC
GTCCAGATGTTTGGCCCGGCCCAGCATGGCGTCGCCATGGCCGTGCAGGACGCGGTTGCC
GAAGGCATCATCCCGGCTGACGAAGCCGACGACCTGTACGTGCTGGTCGGCGTGTTCATC
CACTGGGAAGCGGCCGACGACGCCAAGATCCAGAAGTACAACTACGAGGCCACCAAGCTT
TCGATCCAGCGCGCCGTCAACGGCGAGCCGAAGGCTTCGGTTGTCACGGAGCAGCGTAAG
TCGGCGACCCACCCCTTCGCCGCCAACGCTTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9FA38
UniProtKB Entry NameFAE_METEA
GenBank Protein ID11193064
GenBank Gene IDAF032114
PDB ID(s)1Y5Y, 1Y60
KEGG IDmea:Mex_1p1766
General References
  1. Chistoserdova L, Vorholt JA, Thauer RK, Lidstrom ME: C1 transfer enzymes and coenzymes linking methylotrophic bacteria and methanogenic Archaea. Science. 1998 Jul 3;281(5373):99-102. [Article]
  2. Vuilleumier S, Chistoserdova L, Lee MC, Bringel F, Lajus A, Zhou Y, Gourion B, Barbe V, Chang J, Cruveiller S, Dossat C, Gillett W, Gruffaz C, Haugen E, Hourcade E, Levy R, Mangenot S, Muller E, Nadalig T, Pagni M, Penny C, Peyraud R, Robinson DG, Roche D, Rouy Z, Saenampechek C, Salvignol G, Vallenet D, Wu Z, Marx CJ, Vorholt JA, Olson MV, Kaul R, Weissenbach J, Medigue C, Lidstrom ME: Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources. PLoS One. 2009;4(5):e5584. doi: 10.1371/journal.pone.0005584. Epub 2009 May 18. [Article]
  3. Vorholt JA, Marx CJ, Lidstrom ME, Thauer RK: Novel formaldehyde-activating enzyme in Methylobacterium extorquens AM1 required for growth on methanol. J Bacteriol. 2000 Dec;182(23):6645-50. [Article]
  4. Acharya P, Goenrich M, Hagemeier CH, Demmer U, Vorholt JA, Thauer RK, Ermler U: How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1. J Biol Chem. 2005 Apr 8;280(14):13712-9. Epub 2005 Jan 4. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
5,10-Dimethylene TetrahydromethanopterinexperimentalunknowntargetDetails