5,6,7,8-tetrahydromethanopterin hydro-lyase

BE0001722ProteinMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)fae

Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. It is acted on by 1 drug in DrugBank.

Gene name
fae
UniProtKB entry
Q9FA38Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
170 residues · 18,091 Da
Also known as
4.2.1.147 · Fae · Formaldehyde-activating enzyme

Resolves to

Protein
UniProtQ9FA38UniProt nameFAE_METEA
Gene
GenBank11193064
Pharmacology
KEGGmea:Mex_1p1766
Structure
PDB1Y5YPDB1Y60
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 5,6,7,8-tetrahydromethanopterin hydro-lyase, and which indications are they being tested in?

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