Genome polyprotein

Details

Name
Genome polyprotein
Kind
protein
Synonyms
  • 3.4.22.-
  • p23
Gene Name
Not Available
UniProtKB Entry
P26660Swiss-Prot
Organism
HCV
NCBI Taxonomy ID
11113
Amino acid sequence
>lcl|BSEQ0019171|Genome polyprotein
MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRG
RRQPIPKDRRSTGKSWGKPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPNDPRHRSRNVG
KVIDTLTCGFADLMGYIPVVGAPLGGVARALAHGVRVLEDGVNFATGNLPGCSFSIFLLA
LLSCITTPVSAAEVKNISTGYMVTNDCTNDSITWQLQAAVLHVPGCVPCEKVGNTSRCWI
PVSPNVAVQQPGALTQGLRTHIDMVVMSATLCSALYVGDLCGGVMLAAQMFIVSPQHHWF
VQDCNCSIYPGTITGHRMAWDMMMNWSPTATMILAYAMRVPEVIIDIIGGAHWGVMFGLA
YFSMQGAWAKVVVILLLAAGVDAQTHTVGGSTAHNARTLTGMFSLGARQKIQLINTNGSW
HINRTALNCNDSLHTGFLASLFYTHSFNSSGCPERMSACRSIEAFRVGWGALQYEDNVTN
PEDMRPYCWHYPPRQCGVVSASSVCGPVYCFTPSPVVVGTTDRLGAPTYTWGENETDVFL
LNSTRPPQGSWFGCTWMNSTGYTKTCGAPPCRIRADFNASMDLLCPTDCFRKHPDTTYIK
CGSGPWLTPRCLIDYPYRLWHYPCTVNYTIFKIRMYVGGVEHRLTAACNFTRGDRCNLED
RDRSQLSPLLHSTTEWAILPCTYSDLPALSTGLLHLHQNIVDVQFMYGLSPALTKYIVRW
EWVVLLFLLLADARVCACLWMLILLGQAEAALEKLVVLHAASAASCNGFLYFVIFFVAAW
YIKGRVVPLATYSLTGLWSFGLLLLALPQQAYAYDASVHGQIGAALLVLITLFTLTPGYK
TLLSRFLWWLCYLLTLAEAMVQEWAPPMQVRGGRDGIIWAVAIFCPGVVFDITKWLLAVL
GPAYLLKGALTRVPYFVRAHALLRMCTMVRHLAGGRYVQMVLLALGRWTGTYIYDHLTPM
SDWAANGLRDLAVAVEPIIFSPMEKKVIVWGAETAACGDILHGLPVSARLGREVLLGPAD
GYTSKGWSLLAPITAYAQQTRGLLGTIVVSMTGRDKTEQAGEIQVLSTVTQSFLGTTISG
VLWTVYHGAGNKTLAGSRGPVTQMYSSAEGDLVGWPSPPGTKSLEPCTCGAVDLYLVTRN
ADVIPARRRGDKRGALLSPRPLSTLKGSSGGPVLCPRGHAVGVFRAAVCSRGVAKSIDFI
PVETLDIVTRSPTFSDNSTPPAVPQTYQVGYLHAPTGSGKSTKVPVAYAAQGYKVLVLNP
SVAATLGFGAYLSKAHGINPNIRTGVRTVTTGAPITYSTYGKFLADGGCAGGAYDIIICD
ECHAVDSTTILGIGTVLDQAETAGVRLTVLATATPPGSVTTPHPNIEEVALGQEGEIPFY
GRAIPLSYIKGGRHLIFCHSKKKCDELAAALRGMGLNAVAYYRGLDVSVIPTQGDVVVVA
TDALMTGFTGDFDSVIDCNVAVTQVVDFSLDPTFTITTQTVPQDAVSRSQRRGRTGRGRL
GIYRYVSTGERASGMFDSVVLCECYDAGAAWYELTPAETTVRLRAYFNTPGLPVCQDHLE
FWEAVFTGLTHIDAHFLSQTKQSGENFAYLTAYQATVCARAKAPPPSWDVMWKCLTRLKP
TLVGPTPLLYRLGSVTNEVTLTHPVTKYIATCMQADLEVMTSTWVLAGGVLAAVAAYCLA
TGCVCIIGRLHVNQRAVVAPDKEVLYEAFDEMEECASRAALIEEGQRIAEMLKSKIQGLL
QQASKQAQDIQPAVQASWPKVEQFWAKHMWNFISGIQYLAGLSTLPGNPAVASMMAFSAA
LTSPLSTSTTILLNILGGWLASQIAPPAGATGFVVSGLVGAAVGSIGLGKVLVDILAGYG
AGISGALVAFKIMSGEKPSMEDVVNLLPGILSPGALVVGVICAAILRRHVGPGEGAVQWM
NRLIAFASRGNHVAPTHYVTESDASQRVTQLLGSLTITSLLRRLHNWITEDCPIPCSGSW
LRDVWDWVCTILTDFKNWLTSKLFPKMPGLPFISCQKGYKGVWAGTGIMTTRCPCGANIS
GNVRLGSMRITGPKTCMNIWQGTFPINCYTEGQCVPKPAPNFKIAIWRVAASEYAEVTQH
GSYHYITGLTTDNLKVPCQLPSPEFFSWVDGVQIHRFAPIPKPFFRDEVSFCVGLNSFVV
GSQLPCDPEPDTDVLTSMLTDPSHITAETAARRLARGSPPSEASSSASQLSAPSLRATCT
THGKAYDVDMVDANLFMGGDVTRIESESKVVVLDSLDPMVEERSDLEPSIPSEYMLPKKR
FPPALPAWARPDYNPPLVESWKRPDYQPATVAGCALPPPKKTPTPPPRRRRTVGLSESSI
ADALQQLAIKSFGQPPPSGDSGLSTGADAADSGSRTPPDELALSETGSISSMPPLEGEPG
DPDLEPEQVELQPPPQGGVVTPGSGSGSWSTCSEEDDSVVCCSMSYSWTGALITPCSPEE
EKLPINPLSNSLLRYHNKVYCTTSKSASLRAKKVTFDRMQALDAHYDSVLKDIKLAASKV
TARLLTLEEACQLTPPHSARSKYGFGAKEVRSLSGRAVNHIKSVWKDLLEDTQTPIPTTI
MAKNEVFCVDPTKGGKKAARLIVYPDLGVRVCEKMALYDITQKLPQAVMGASYGFQYSPA
QRVEFLLKAWAEKKDPMGFSYDTRCFDSTVTERDIRTEESIYRACSLPEEAHTAIHSLTE
RLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKALAACKAAGIIAPTMLVCGD
DLVVISESQGTEEDERNLRAFTEAMTRYSAPPGDPPRPEYDLELITSCSSNVSVALGPQG
RRRYYLTRDPTTPIARAAWETVRHSPVNSWLGNIIQYAPTIWARMVLMTHFFSILMAQDT
LDQNLNFEMYGAVYSVSPLDLPAIIERLHGLDAFSLHTYTPHELTRVASALRKLGAPPLR
AWKSRARAVRASLISRGGRAAVCGRYLFNWAVKTKLKLTPLPEARLLDLSSWFTVGAGGG
DIYHSVSRARPRLLLLGLLLLFVGVGLFLLPAR
Number of residues
3033
Molecular Weight
329166.12
Theoretical pI
8.26
GO Classification
Functions
ATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / structural molecule activity / zinc ion binding
Processes
apoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / modulation by virus of host G1/S transition checkpoint / pore formation by virus in membrane of host cell / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transformation of host cell by virus / viral process / viral RNA genome replication / virion attachment to host cell
Components
extracellular region / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell mitochondrial membrane / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
General Function
Mature core protein Packages viral RNA to form a viral nucleocapsid, and promotes virion budding (Probable). Participates in the viral particle production as a result of its interaction with the non-structural protein 5A (By similarity). Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication (By similarity). Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit (By similarity). Affects various cell signaling pathways, host immunity and lipid metabolism (Probable). Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by blocking the formation of phosphorylated STAT1 and promoting ubiquitin-mediated proteasome-dependent degradation of STAT1 (By similarity). Activates STAT3 leading to cellular transformation (By similarity). Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm (By similarity). Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation (By similarity). Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses TNF-induced NF-kappa-B activation, and activates AP-1 (By similarity). Binds to dendritic cells (DCs) via C1QR1, resulting in down-regulation of T-lymphocytes proliferation (By similarity). Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage (By similarity). Induces up-regulation of FAS promoter activity, and thereby contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
169-189 359-379 730-750 762-782 787-807 818-838 886-906 933-953 1662-1682 1810-1830 1833-1853 1855-1875 1886-1906 3013-3033
Cellular Location
Host endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0003428|9102 bp
ATGAGCACAAATCCTAAACCTCAAAGAAAAACCAAAAGAAACACCAACCGTCGCCCACAA
GACGTTAAGTTTCCGGGCGGCGGCCAGATCGTTGGCGGAGTATACTTGTTGCCGCGCAGG
GGCCCCAGGTTGGGTGTGCGCGCGACAAGGAAGACTTCGGAGCGGTCCCAGCCACGTGGA
AGGCGCCAGCCCATCCCTAAGGATCGGCGCTCCACTGGCAAATCCTGGGGAAAACCAGGA
TACCCCTGGCCCCTATACGGGAATGAGGGACTCGGCTGGGCAGGATGGCTCCTGTCCCCC
CGAGGTTCCCGTCCCTCTTGGGGCCCCAATGACCCCCGGCATAGGTCCCGCAACGTGGGT
AAGGTCATCGATACCCTAACGTGCGGCTTTGCCGACCTCATGGGGTACATCCCTGTCGTA
GGCGCCCCGCTCGGCGGCGTCGCCAGAGCTCTCGCGCATGGCGTGAGAGTCCTGGAGGAC
GGGGTTAATTTTGCAACAGGGAACTTACCCGGTTGCTCCTTTTCTATCTTCTTGCTGGCC
CTGCTGTCCTGCATCACCACCCCGGTCTCCGCTGCCGAAGTGAAGAACATCAGTACCGGC
TACATGGTGACCAACGACTGCACCAATGATAGCATTACCTGGCAACTCCAGGCTGCTGTC
CTCCACGTCCCCGGGTGCGTCCCGTGCGAGAAAGTGGGGAATACATCTCGGTGCTGGATA
CCGGTCTCACCGAATGTGGCCGTGCAGCAGCCCGGCGCCCTCACGCAGGGCTTACGGACG
CACATTGACATGGTTGTGATGTCCGCCACGCTCTGCTCCGCTCTTTACGTGGGGGACCTC
TGCGGTGGGGTGATGCTTGCAGCCCAGATGTTCATTGTCTCGCCACAGCACCACTGGTTT
GTGCAAGACTGCAATTGCTCCATCTACCCTGGTACCATCACTGGACACCGCATGGCGTGG
GACATGATGATGAACTGGTCGCCCACGGCTACCATGATCCTGGCGTACGCGATGCGCGTC
CCCGAGGTCATCATAGACATCATTGGCGGGGCTCATTGGGGCGTCATGTTCGGCTTAGCC
TACTTCTCTATGCAGGGAGCGTGGGCAAAAGTCGTTGTCATTCTTTTGCTGGCCGCCGGG
GTGGACGCGCAAACCCATACCGTTGGGGGTTCTACCGCGCATAACGCCAGGACCCTCACC
GGCATGTTCTCCCTTGGTGCCAGGCAGAAAATCCAGCTCATCAACACCAATGGCAGTTGG
CACATCAACCGCACCGCCCTGAACTGCAATGACTCTTTGCACACCGGCTTCCTCGCGTCA
CTGTTCTACACCCACAGCTTCAACTCGTCAGGATGTCCCGAACGCATGTCCGCCTGCCGC
AGTATCGAGGCCTTTCGGGTGGGATGGGGCGCCTTACAATATGAGGACAATGTCACCAAT
CCAGAGGATATGAGACCGTATTGCTGGCACTACCCACCAAGACAGTGTGGTGTAGTCTCC
GCGAGCTCTGTGTGTGGCCCAGTGTACTGTTTCACCCCCAGCCCAGTAGTAGTGGGTACG
ACCGATAGACTTGGAGCGCCCACTTACACGTGGGGGGAGAATGAGACAGATGTCTTCCTA
TTGAACAGCACTCGACCACCGCAGGGGTCATGGTTCGGCTGCACGTGGATGAACTCCACT
GGCTACACCAAGACTTGCGGCGCACCACCCTGCCGCATTAGAGCTGACTTCAATGCCAGC
ATGGACTTGTTGTGCCCCACGGACTGTTTTAGGAAGCATCCTGATACCACCTACATCAAA
TGTGGCTCTGGGCCCTGGCTCACGCCAAGGTGCCTGATCGACTACCCCTACAGGCTCTGG
CATTACCCCTGCACAGTTAACTATACCATCTTCAAAATAAGGATGTATGTGGGGGGGGTC
GAGCACAGGCTCACGGCTGCGTGCAATTTCACTCGTGGGGATCGTTGCAACTTGGAGGAC
AGAGACAGAAGTCAACTGTCTCCTTTGCTGCACTCCACCACGGAGTGGGCCATTTTACCT
TGCACTTACTCGGACCTGCCCGCCTTGTCGACTGGTCTTCTCCACCTCCACCAAAACATC
GTGGACGTGCAATTCATGTATGGCCTATCACCTGCTCTCACAAAATACATCGTCCGATGG
GAGTGGGTAGTACTCTTATTCCTGCTCTTAGCGGACGCCAGGGTTTGCGCCTGCTTATGG
ATGCTCATCTTGTTGGGCCAGGCCGAAGCAGCACTAGAGAAGTTGGTCGTCTTGCACGCT
GCGAGCGCAGCTAGCTGCAATGGCTTCCTATACTTTGTCATCTTTTTCGTGGCTGCTTGG
TACATCAAGGGTCGGGTAGTCCCCTTGGCTACTTATTCCCTCACTGGCCTATGGTCCTTT
GGCCTACTGCTCCTAGCATTGCCCCAACAGGCTTATGCTTATGACGCATCTGTACATGGT
CAGATAGGAGCAGCTCTGTTGGTACTGATCACTCTCTTTACACTCACCCCCGGGTATAAG
ACCCTTCTCAGCCGGTTTCTGTGGTGGTTGTGCTATCTTCTGACCCTGGCGGAAGCTATG
GTCCAGGAGTGGGCACCACCTATGCAGGTGCGCGGTGGCCGTGATGGGATCATATGGGCC
GTCGCCATATTCTGCCCGGGTGTGGTGTTTGACATAACCAAGTGGCTCTTGGCGGTGCTT
GGGCCTGCTTATCTCCTAAAAGGTGCTTTGACGCGTGTGCCGTACTTCGTCAGGGCTCAC
GCTCTACTAAGGATGTGCACCATGGTAAGGCATCTCGCGGGGGGTAGGTACGTCCAGATG
GTGCTACTAGCCCTTGGCAGGTGGACTGGCACTTACATCTATGACCACCTCACCCCTATG
TCGGATTGGGCTGCTAATGGCCTGCGGGACTTGGCGGTCGCCGTGGAGCCTATCATCTTC
AGTCCGATGGAGAAAAAAGTCATCGTCTGGGGAGCGGAGACAGCTGCTTGCGGGGATATC
TTACACGGACTTCCCGTGTCCGCCCGACTTGGCCGGGAGGTCCTCCTTGGCCCAGCTGAT
GGCTATACCTCCAAGGGGTGGAGTCTTCTCGCCCCCATCACTGCTTATGCCCAGCAGACA
CGCGGCCTTTTGGGCACCATAGTGGTGAGCATGACGGGGCGCGACAAGACAGAACAGGCC
GGGGAGATTCAGGTCCTGTCCACGGTCACTCAGTCCTTCCTCGGAACAACCATCTCGGGG
GTCTTATGGACTGTCTACCATGGAGCTGGCAACAAGACTCTAGCCGGCTCACGGGGTCCG
GTCACACAGATGTACTCCAGTGCTGAGGGGGACTTAGTGGGGTGGCCCAGCCCCCCCGGG
ACCAAATCTTTGGAGCCGTGCACGTGTGGAGCGGTCGACCTATACCTGGTCACGCGAAAC
GCTGATGTCATCCCGGCTCGAAGACGCGGGGACAAGCGAGGAGCGCTACTCTCCCCGAGA
CCTCTTTCCACCTTGAAGGGGTCCTCGGGGGGCCCGGTGCTCTGCCCCAGAGGCCACGCT
GTCGGGGTCTTCCGGGCAGCCGTGTGCTCCCGGGGCGTGGCCAAGTCCATAGATTTTATC
CCCGTTGAGACACTTGACATCGTCACTCGGTCCCCCACCTTTAGTGACAACAGCACACCA
CCTGCTGTGCCCCAAACTTATCAGGTCGGGTACTTACATGCCCCGACTGGTAGTGGAAAG
AGCACCAAAGTCCCTGTCGCGTATGCCGCTCAGGGGTACAAAGTGCTAGTGCTTAATCCC
TCGGTGGCTGCCACCCTGGGGTTTGGGGCGTACTTGTCCAAGGCACATGGCATCAATCCC
AACATTAGGACTGGGGTCAGGACTGTGACGACCGGGGCGCCCATCACGTACTCCACATAT
GGCAAATTCCTCGCCGATGGGGGCTGCGCAGGCGGCGCCTATGACATCATCATATGCGAT
GAATGCCATGCCGTGGACTCTACCACCATTCTCGGCATCGGAACAGTCCTCGATCAAGCA
GAGACAGCCGGGGTCAGGCTAACTGTACTGGCTACGGCTACGCCCCCCGGGTCAGTGACA
ACCCCCCACCCCAACATAGAGGAGGTGGCCCTCGGGCAGGAGGGTGAGATCCCCTTCTAT
GGGAGGGCGATTCCCCTGTCATACATCAAGGGAGGAAGACACTTGATCTTCTGCCACTCA
AAGAAAAAGTGTGACGAGCTCGCGGCGGCCCTTCGGGGTATGGGCTTGAACGCAGTGGCA
TACTACAGAGGGCTGGACGTCTCCGTAATACCAACTCAGGGAGACGTAGTGGTCGTCGCC
ACCGACGCCCTCATGACGGGGTTTACTGGAGACTTTGACTCCGTGATCGACTGCAACGTA
GCGGTCACTCAAGTTGTAGACTTCAGCTTGGACCCCACATTCACCATAACCACACAGACT
GTCCCTCAAGACGCTGTCTCACGTAGCCAGCGCCGGGGCCGCACGGGCAGGGGAAGACTG
GGTATTTATAGGTATGTTTCCACTGGTGAGCGAGCCTCAGGAATGTTTGACAGTGTAGTG
CTCTGCGAGTGCTACGATGCAGGGGCCGCATGGTATGAGCTCACACCAGCGGAGACCACC
GTCAGGCTCAGAGCATATTTCAACACACCTGGTTTGCCTGTGTGCCAAGACCATCTTGAG
TTTTGGGAGGCAGTTTTCACCGGCCTCACACACATAGATGCCCACTTCCTTTCCCAAACA
AAGCAATCGGGGGAAAATTTCGCATACTTAACAGCCTACCAGGCTACAGTGTGCGCTAGG
GCCAAAGCCCCCCCCCCGTCCTGGGACGTCATGTGGAAGTGTTTGACTCGACTCAAGCCC
ACACTCGTGGGCCCCACACCTCTCCTGTACCGCTTGGGCTCTGTTACCAACGAGGTCACC
CTCACGCATCCTGTGACGAAATACATCGCCACCTGCATGCAAGCCGACCTTGAGGTCATG
ACCAGCACGTGGGTCTTAGCTGGGGGGGTCTTGGCGGCCGTCGCCGCGTACTGCCTGGCG
ACCGGGTGTGTTTGCATCATCGGCCGCTTGCACGTTAACCAGCGAGCCGTCGTTGCACCG
GACAAGGAGGTCCTCTATGAGGCTTTTGATGAGATGGAGGAATGTGCCTCTAGAGCGGCT
CTCATTGAAGAGGGGCAGCGGATAGCCGAGATGCTGAAGTCCAAGATCCAAGGCTTATTG
CAGCAAGCTTCCAAACAAGCTCAAGACATACAACCCGCTGTGCAGGCTTCTTGGCCCAAG
GTAGAGCAATTCTGGGCCAAACACATGTGGAACTTCATCAGCGGCATTCAATACCTCGCA
GGACTATCAACACTGCCAGGGAACCCTGCTGTAGCTTCCATGATGGCATTCAGTGCCGCC
CTCACCAGTCCGTTGTCAACTAGCACCACTATCCTTCTCAACATTTTGGGGGGCTGGCTA
GCATCCCAAATTGCGCCTCCCGCGGGGGCTACCGGCTTCGTCGTCAGTGGCCTGGTGGGG
GCTGCCGTAGGCAGCATAGGCTTGGGTAAGGTGCTGGTGGACATCCTGGCAGGGTATGGT
GCGGGCATTTCGGGGGCTCTCGTCGCATTCAAGATCATGTCTGGCGAGAAGCCCTCCATG
GAGGATGTTGTCAACCTGCTGCCTGGAATTCTGTCTCCGGGTGCCCTGGTGGTGGGAGTC
ATCTGCGCGGCCATCCTGCGCCGACACGTGGGACCGGGGGAAGGCGCTGTCCAATGGATG
AATAGGCTCATTGCCTTTGCTTCCAGAGGAAACCACGTCGCCCCCACCCACTACGTGACG
GAGTCGGATGCGTCGCAGCGTGTGACCCAACTACTTGGCTCCCTTACCATAACCAGCCTG
CTCAGGAGACTCCACAACTGGATTACTGAAGACTGCCCCATCCCATGCAGCGGCTCGTGG
CTCCGCGATGTGTGGGATTGGGTTTGCACCATCCTAACAGACTTTAAAAACTGGCTGACC
TCCAAATTGTTCCCAAAGATGCCTGGTCTCCCCTTTATCTCTTGTCAAAAGGGGTACAAG
GGCGTGTGGGCTGGCACTGGTATCATGACCACACGGTGTCCTTGCGGCGCCAATATCTCT
GGCAATGTCCGCCTGGGCTCCATGAGAATTACGGGGCCCAAAACCTGCATGAATATCTGG
CAGGGGACCTTTCCCATCAATTGTTACACGGAGGGCCAGTGCGTGCCGAAACCCGCACCA
AACTTTAAGATCGCCATCTGGAGGGTGGCGGCCTCAGAGTACGCGGAGGTGACGCAGCAC
GGGTCATACCACTACATAACAGGACTTACCACTGATAACTTGAAAGTTCCTTGCCAACTA
CCTTCTCCAGAGTTCTTTTCCTGGGTGGACGGAGTGCAGATCCATAGGTTTGCCCCCATA
CCGAAGCCGTTTTTTCGGGATGAGGTCTCGTTCTGCGTTGGGCTTAATTCATTTGTCGTC
GGGTCTCAGCTCCCTTGCGATCCTGAACCTGACACAGACGTATTGACGTCCATGCTAACA
GACCCATCCCATATCACGGCGGAGACTGCAGCGCGGCGTTTGGCACGGGGGTCACCCCCG
TCCGAGGCAAGCTCCTCAGCGAGCCAGCTATCGGCACCATCGCTGCGAGCCACCTGCACC
ACCCACGGCAAGGCCTATGATGTGGACATGGTGGATGCCAACCTGTTCATGGGGGGCGAT
GTGACCCGGATAGAGTCTGAGTCCAAAGTGGTCGTTCTGGACTCTCTCGACCCAATGGTC
GAAGAAAGGAGCGACCTTGAGCCTTCGATACCATCGGAATATATGCTCCCCAAGAAGAGA
TTCCCACCAGCCTTACCGGCTTGGGCACGGCCTGATTACAACCCACCGCTTGTGGAATCG
TGGAAGAGGCCAGATTACCAACCGGCCACTGTTGCGGGCTGCGCTCTCCCCCCCCCTAAG
AAAACCCCGACGCCTCCCCCAAGGAGACGCCGGACAGTGGGTCTGAGTGAGAGCTCCATA
GCAGATGCCCTACAACAGCTGGCCATCAAGTCCTTTGGCCAGCCCCCCCCAAGCGGCGAT
TCAGGCCTTTCCACGGGGGCGGACGCAGCCGATTCCGGCAGTCGGACGCCCCCCGATGAG
TTGGCCCTTTCGGAGACAGGTTCCATCTCCTCCATGCCCCCTCTCGAGGGGGAGCCTGGA
GATCCAGACTTGGAGCCTGAGCAGGTAGAGCTTCAACCTCCCCCCCAGGGGGGGGTGGTA
ACCCCCGGCTCAGGCTCGGGGTCTTGGTCTACTTGCTCCGAGGAGGACGACTCCGTCGTG
TGCTGCTCCATGTCATACTCCTGGACCGGGGCTCTAATAACTCCTTGTAGCCCCGAAGAG
GAAAAGTTGCCAATTAACCCCTTGAGCAACTCCCTGTTGCGATATCACAACAAGGTGTAC
TGTACCACATCAAAGAGCGCCTCATTAAGGGCTAAAAAGGTAACTTTTGATAGGATGCAA
GCGCTCGACGCTCATTATGACTCAGTCTTGAAGGACATTAAGCTAGCGGCCTCCAAGGTC
ACCGCAAGGCTTCTCACTTTAGAGGAGGCCTGCCAGTTAACTCCACCCCACTCTGCAAGA
TCCAAGTATGGGTTTGGGGCTAAGGAGGTCCGCAGCTTGTCCGGGAGAGCCGTTAACCAC
ATCAAGTCCGTGTGGAAGGACCTCCTGGAAGACACACAAACACCAATTCCTACAACCATC
ATGGCCAAAAATGAGGTGTTCTGCGTGGACCCCACCAAGGGGGGTAAGAAAGCAGCTCGC
CTTATCGTTTACCCTGACCTCGGCGTCAGGGTCTGCGAGAAAATGGCCCTTTATGATATC
ACACAAAAGCTTCCTCAGGCGGTGATGGGGGCTTCTTATGGATTCCAGTACTCCCCCGCT
CAGCGGGTGGAGTTTCTCTTGAAGGCATGGGCGGAAAAGAAAGACCCTATGGGTTTTTCG
TATGATACCCGATGCTTTGACTCAACCGTCACTGAGAGAGACATCAGGACTGAGGAGTCC
ATATATCGGGCTTGTTCCTTGCCCGAGGAGGCCCACACTGCCATACACTCACTGACTGAG
AGACTTTACGTGGGAGGGCCCATGTTCAACAGCAAGGGCCAGACCTGCGGGTACAGGCGT
TGCCGCGCCAGCGGGGTGCTTACCACTAGCATGGGGAACACCATCACATGCTATGTGAAA
GCCTTAGCGGCCTGTAAGGCTGCAGGGATAATTGCGCCCACAATGCTGGTATGCGGCGAT
GACTTGGTTGTCATCTCAGAGAGCCAGGGGACCGAGGAGGACGAGCGGAACCTGAGAGCC
TTCACGGAGGCTATGACCAGGTATTCTGCCCCTCCTGGTGACCCCCCCAGACCGGAATAT
GACCTGGAGCTGATAACATCTTGCTCCTCAAATGTGTCTGTGGCGTTGGGCCCACAAGGC
CGCCGCAGATACTACCTGACCAGAGACCCTACCACTCCAATCGCCCGGGCTGCCTGGGAA
ACAGTTAGACACTCCCCTGTCAATTCATGGCTAGGAAACATCATCCAGTACGCCCCAACC
ATATGGGCTCGCATGGTCCTGATGACACACTTCTTCTCCATTCTCATGGCCCAAGATACT
CTGGACCAGAACCTCAACTTTGAGATGTACGGAGCGGTGTACTCCGTGAGTCCCTTGGAC
CTCCCAGCCATAATTGAAAGGTTACACGGGCTTGACGCTTTCTCTCTGCACACATACACT
CCCCACGAACTGACACGGGTGGCTTCAGCCCTCAGAAAACTTGGGGCGCCACCCCTCAGA
GCGTGGAAGAGCCGGGCACGTGCAGTCAGGGCGTCCCTCATCTCCCGTGGGGGGAGAGCG
GCCGTTTGCGGCCGATATCTCTTCAACTGGGCGGTGAAGACCAAGCTCAAACTCACTCCA
TTGCCGGAAGCGCGCCTCCTGGATTTATCCAGCTGGTTCACTGTCGGCGCCGGCGGGGGC
GACATTTATCACAGCGTGTCGCGTGCCCGACCCCGCTTATTACTCCTTGGCCTACTCCTA
CTTTTTGTAGGGGTAGGCCTTTTCCTACTCCCCGCTCGGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP26660
UniProtKB Entry NamePOLG_HCVJ6
GenBank Protein ID221651
GenBank Gene IDD00944
PDB ID(s)1YUY, 1YV2, 1YVX, 1YVZ, 2XWH, 4ADP
General References
  1. Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, Miyakawa Y, Mayumi M: Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions. J Gen Virol. 1991 Nov;72 ( Pt 11):2697-704. [Article]
  2. Kim CS, Seol SK, Song OK, Park JH, Jang SK: An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. J Virol. 2007 Apr;81(8):3852-65. Epub 2007 Jan 17. [Article]
  3. Evans MJ, von Hahn T, Tscherne DM, Syder AJ, Panis M, Wolk B, Hatziioannou T, McKeating JA, Bieniasz PD, Rice CM: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature. 2007 Apr 12;446(7137):801-5. Epub 2007 Feb 25. [Article]
  4. McLauchlan J: Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J Viral Hepat. 2000 Jan;7(1):2-14. [Article]
  5. Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM: Structural biology of hepatitis C virus. Hepatology. 2004 Jan;39(1):5-19. [Article]
  6. Biswal BK, Cherney MM, Wang M, Chan L, Yannopoulos CG, Bilimoria D, Nicolas O, Bedard J, James MN: Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem. 2005 May 6;280(18):18202-10. Epub 2005 Mar 2. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
3-[(2,4-Dichlorobenzoyl)(Isopropyl)Amino]-5-Phenylthiophene-2-Carboxylic AcidexperimentalunknowntargetDetails
3-[Isopropyl(4-Methylbenzoyl)Amino]-5-Phenylthiophene-2-Carboxylic AcidexperimentalunknowntargetDetails