Genome polyprotein
Details
- Name
- Genome polyprotein
- Kind
- protein
- Synonyms
- 3.4.22.-
- p23
- Gene Name
- Not Available
- UniProtKB Entry
- P26660Swiss-Prot
- Organism
- HCV
- NCBI Taxonomy ID
- 11113
- Amino acid sequence
>lcl|BSEQ0019171|Genome polyprotein MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRG RRQPIPKDRRSTGKSWGKPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPNDPRHRSRNVG KVIDTLTCGFADLMGYIPVVGAPLGGVARALAHGVRVLEDGVNFATGNLPGCSFSIFLLA LLSCITTPVSAAEVKNISTGYMVTNDCTNDSITWQLQAAVLHVPGCVPCEKVGNTSRCWI PVSPNVAVQQPGALTQGLRTHIDMVVMSATLCSALYVGDLCGGVMLAAQMFIVSPQHHWF VQDCNCSIYPGTITGHRMAWDMMMNWSPTATMILAYAMRVPEVIIDIIGGAHWGVMFGLA YFSMQGAWAKVVVILLLAAGVDAQTHTVGGSTAHNARTLTGMFSLGARQKIQLINTNGSW HINRTALNCNDSLHTGFLASLFYTHSFNSSGCPERMSACRSIEAFRVGWGALQYEDNVTN PEDMRPYCWHYPPRQCGVVSASSVCGPVYCFTPSPVVVGTTDRLGAPTYTWGENETDVFL LNSTRPPQGSWFGCTWMNSTGYTKTCGAPPCRIRADFNASMDLLCPTDCFRKHPDTTYIK CGSGPWLTPRCLIDYPYRLWHYPCTVNYTIFKIRMYVGGVEHRLTAACNFTRGDRCNLED RDRSQLSPLLHSTTEWAILPCTYSDLPALSTGLLHLHQNIVDVQFMYGLSPALTKYIVRW EWVVLLFLLLADARVCACLWMLILLGQAEAALEKLVVLHAASAASCNGFLYFVIFFVAAW YIKGRVVPLATYSLTGLWSFGLLLLALPQQAYAYDASVHGQIGAALLVLITLFTLTPGYK TLLSRFLWWLCYLLTLAEAMVQEWAPPMQVRGGRDGIIWAVAIFCPGVVFDITKWLLAVL GPAYLLKGALTRVPYFVRAHALLRMCTMVRHLAGGRYVQMVLLALGRWTGTYIYDHLTPM SDWAANGLRDLAVAVEPIIFSPMEKKVIVWGAETAACGDILHGLPVSARLGREVLLGPAD GYTSKGWSLLAPITAYAQQTRGLLGTIVVSMTGRDKTEQAGEIQVLSTVTQSFLGTTISG VLWTVYHGAGNKTLAGSRGPVTQMYSSAEGDLVGWPSPPGTKSLEPCTCGAVDLYLVTRN ADVIPARRRGDKRGALLSPRPLSTLKGSSGGPVLCPRGHAVGVFRAAVCSRGVAKSIDFI PVETLDIVTRSPTFSDNSTPPAVPQTYQVGYLHAPTGSGKSTKVPVAYAAQGYKVLVLNP SVAATLGFGAYLSKAHGINPNIRTGVRTVTTGAPITYSTYGKFLADGGCAGGAYDIIICD ECHAVDSTTILGIGTVLDQAETAGVRLTVLATATPPGSVTTPHPNIEEVALGQEGEIPFY GRAIPLSYIKGGRHLIFCHSKKKCDELAAALRGMGLNAVAYYRGLDVSVIPTQGDVVVVA TDALMTGFTGDFDSVIDCNVAVTQVVDFSLDPTFTITTQTVPQDAVSRSQRRGRTGRGRL GIYRYVSTGERASGMFDSVVLCECYDAGAAWYELTPAETTVRLRAYFNTPGLPVCQDHLE FWEAVFTGLTHIDAHFLSQTKQSGENFAYLTAYQATVCARAKAPPPSWDVMWKCLTRLKP TLVGPTPLLYRLGSVTNEVTLTHPVTKYIATCMQADLEVMTSTWVLAGGVLAAVAAYCLA TGCVCIIGRLHVNQRAVVAPDKEVLYEAFDEMEECASRAALIEEGQRIAEMLKSKIQGLL QQASKQAQDIQPAVQASWPKVEQFWAKHMWNFISGIQYLAGLSTLPGNPAVASMMAFSAA LTSPLSTSTTILLNILGGWLASQIAPPAGATGFVVSGLVGAAVGSIGLGKVLVDILAGYG AGISGALVAFKIMSGEKPSMEDVVNLLPGILSPGALVVGVICAAILRRHVGPGEGAVQWM NRLIAFASRGNHVAPTHYVTESDASQRVTQLLGSLTITSLLRRLHNWITEDCPIPCSGSW LRDVWDWVCTILTDFKNWLTSKLFPKMPGLPFISCQKGYKGVWAGTGIMTTRCPCGANIS GNVRLGSMRITGPKTCMNIWQGTFPINCYTEGQCVPKPAPNFKIAIWRVAASEYAEVTQH GSYHYITGLTTDNLKVPCQLPSPEFFSWVDGVQIHRFAPIPKPFFRDEVSFCVGLNSFVV GSQLPCDPEPDTDVLTSMLTDPSHITAETAARRLARGSPPSEASSSASQLSAPSLRATCT THGKAYDVDMVDANLFMGGDVTRIESESKVVVLDSLDPMVEERSDLEPSIPSEYMLPKKR FPPALPAWARPDYNPPLVESWKRPDYQPATVAGCALPPPKKTPTPPPRRRRTVGLSESSI ADALQQLAIKSFGQPPPSGDSGLSTGADAADSGSRTPPDELALSETGSISSMPPLEGEPG DPDLEPEQVELQPPPQGGVVTPGSGSGSWSTCSEEDDSVVCCSMSYSWTGALITPCSPEE EKLPINPLSNSLLRYHNKVYCTTSKSASLRAKKVTFDRMQALDAHYDSVLKDIKLAASKV TARLLTLEEACQLTPPHSARSKYGFGAKEVRSLSGRAVNHIKSVWKDLLEDTQTPIPTTI MAKNEVFCVDPTKGGKKAARLIVYPDLGVRVCEKMALYDITQKLPQAVMGASYGFQYSPA QRVEFLLKAWAEKKDPMGFSYDTRCFDSTVTERDIRTEESIYRACSLPEEAHTAIHSLTE RLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKALAACKAAGIIAPTMLVCGD DLVVISESQGTEEDERNLRAFTEAMTRYSAPPGDPPRPEYDLELITSCSSNVSVALGPQG RRRYYLTRDPTTPIARAAWETVRHSPVNSWLGNIIQYAPTIWARMVLMTHFFSILMAQDT LDQNLNFEMYGAVYSVSPLDLPAIIERLHGLDAFSLHTYTPHELTRVASALRKLGAPPLR AWKSRARAVRASLISRGGRAAVCGRYLFNWAVKTKLKLTPLPEARLLDLSSWFTVGAGGG DIYHSVSRARPRLLLLGLLLLFVGVGLFLLPAR
- Number of residues
- 3033
- Molecular Weight
- 329166.12
- Theoretical pI
- 8.26
- GO Classification
- FunctionsATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / structural molecule activity / zinc ion bindingProcessesapoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / modulation by virus of host G1/S transition checkpoint / pore formation by virus in membrane of host cell / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transformation of host cell by virus / viral process / viral RNA genome replication / virion attachment to host cellComponentsextracellular region / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell mitochondrial membrane / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
- General Function
- Mature core protein Packages viral RNA to form a viral nucleocapsid, and promotes virion budding (Probable). Participates in the viral particle production as a result of its interaction with the non-structural protein 5A (By similarity). Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication (By similarity). Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit (By similarity). Affects various cell signaling pathways, host immunity and lipid metabolism (Probable). Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by blocking the formation of phosphorylated STAT1 and promoting ubiquitin-mediated proteasome-dependent degradation of STAT1 (By similarity). Activates STAT3 leading to cellular transformation (By similarity). Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm (By similarity). Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation (By similarity). Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses TNF-induced NF-kappa-B activation, and activates AP-1 (By similarity). Binds to dendritic cells (DCs) via C1QR1, resulting in down-regulation of T-lymphocytes proliferation (By similarity). Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage (By similarity). Induces up-regulation of FAS promoter activity, and thereby contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 169-189 359-379 730-750 762-782 787-807 818-838 886-906 933-953 1662-1682 1810-1830 1833-1853 1855-1875 1886-1906 3013-3033
- Cellular Location
- Host endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0003428|9102 bp ATGAGCACAAATCCTAAACCTCAAAGAAAAACCAAAAGAAACACCAACCGTCGCCCACAA GACGTTAAGTTTCCGGGCGGCGGCCAGATCGTTGGCGGAGTATACTTGTTGCCGCGCAGG GGCCCCAGGTTGGGTGTGCGCGCGACAAGGAAGACTTCGGAGCGGTCCCAGCCACGTGGA AGGCGCCAGCCCATCCCTAAGGATCGGCGCTCCACTGGCAAATCCTGGGGAAAACCAGGA TACCCCTGGCCCCTATACGGGAATGAGGGACTCGGCTGGGCAGGATGGCTCCTGTCCCCC CGAGGTTCCCGTCCCTCTTGGGGCCCCAATGACCCCCGGCATAGGTCCCGCAACGTGGGT AAGGTCATCGATACCCTAACGTGCGGCTTTGCCGACCTCATGGGGTACATCCCTGTCGTA GGCGCCCCGCTCGGCGGCGTCGCCAGAGCTCTCGCGCATGGCGTGAGAGTCCTGGAGGAC GGGGTTAATTTTGCAACAGGGAACTTACCCGGTTGCTCCTTTTCTATCTTCTTGCTGGCC CTGCTGTCCTGCATCACCACCCCGGTCTCCGCTGCCGAAGTGAAGAACATCAGTACCGGC TACATGGTGACCAACGACTGCACCAATGATAGCATTACCTGGCAACTCCAGGCTGCTGTC CTCCACGTCCCCGGGTGCGTCCCGTGCGAGAAAGTGGGGAATACATCTCGGTGCTGGATA CCGGTCTCACCGAATGTGGCCGTGCAGCAGCCCGGCGCCCTCACGCAGGGCTTACGGACG CACATTGACATGGTTGTGATGTCCGCCACGCTCTGCTCCGCTCTTTACGTGGGGGACCTC TGCGGTGGGGTGATGCTTGCAGCCCAGATGTTCATTGTCTCGCCACAGCACCACTGGTTT GTGCAAGACTGCAATTGCTCCATCTACCCTGGTACCATCACTGGACACCGCATGGCGTGG GACATGATGATGAACTGGTCGCCCACGGCTACCATGATCCTGGCGTACGCGATGCGCGTC CCCGAGGTCATCATAGACATCATTGGCGGGGCTCATTGGGGCGTCATGTTCGGCTTAGCC TACTTCTCTATGCAGGGAGCGTGGGCAAAAGTCGTTGTCATTCTTTTGCTGGCCGCCGGG GTGGACGCGCAAACCCATACCGTTGGGGGTTCTACCGCGCATAACGCCAGGACCCTCACC GGCATGTTCTCCCTTGGTGCCAGGCAGAAAATCCAGCTCATCAACACCAATGGCAGTTGG CACATCAACCGCACCGCCCTGAACTGCAATGACTCTTTGCACACCGGCTTCCTCGCGTCA CTGTTCTACACCCACAGCTTCAACTCGTCAGGATGTCCCGAACGCATGTCCGCCTGCCGC AGTATCGAGGCCTTTCGGGTGGGATGGGGCGCCTTACAATATGAGGACAATGTCACCAAT CCAGAGGATATGAGACCGTATTGCTGGCACTACCCACCAAGACAGTGTGGTGTAGTCTCC GCGAGCTCTGTGTGTGGCCCAGTGTACTGTTTCACCCCCAGCCCAGTAGTAGTGGGTACG ACCGATAGACTTGGAGCGCCCACTTACACGTGGGGGGAGAATGAGACAGATGTCTTCCTA TTGAACAGCACTCGACCACCGCAGGGGTCATGGTTCGGCTGCACGTGGATGAACTCCACT GGCTACACCAAGACTTGCGGCGCACCACCCTGCCGCATTAGAGCTGACTTCAATGCCAGC ATGGACTTGTTGTGCCCCACGGACTGTTTTAGGAAGCATCCTGATACCACCTACATCAAA TGTGGCTCTGGGCCCTGGCTCACGCCAAGGTGCCTGATCGACTACCCCTACAGGCTCTGG CATTACCCCTGCACAGTTAACTATACCATCTTCAAAATAAGGATGTATGTGGGGGGGGTC GAGCACAGGCTCACGGCTGCGTGCAATTTCACTCGTGGGGATCGTTGCAACTTGGAGGAC AGAGACAGAAGTCAACTGTCTCCTTTGCTGCACTCCACCACGGAGTGGGCCATTTTACCT TGCACTTACTCGGACCTGCCCGCCTTGTCGACTGGTCTTCTCCACCTCCACCAAAACATC GTGGACGTGCAATTCATGTATGGCCTATCACCTGCTCTCACAAAATACATCGTCCGATGG GAGTGGGTAGTACTCTTATTCCTGCTCTTAGCGGACGCCAGGGTTTGCGCCTGCTTATGG ATGCTCATCTTGTTGGGCCAGGCCGAAGCAGCACTAGAGAAGTTGGTCGTCTTGCACGCT GCGAGCGCAGCTAGCTGCAATGGCTTCCTATACTTTGTCATCTTTTTCGTGGCTGCTTGG TACATCAAGGGTCGGGTAGTCCCCTTGGCTACTTATTCCCTCACTGGCCTATGGTCCTTT GGCCTACTGCTCCTAGCATTGCCCCAACAGGCTTATGCTTATGACGCATCTGTACATGGT CAGATAGGAGCAGCTCTGTTGGTACTGATCACTCTCTTTACACTCACCCCCGGGTATAAG ACCCTTCTCAGCCGGTTTCTGTGGTGGTTGTGCTATCTTCTGACCCTGGCGGAAGCTATG GTCCAGGAGTGGGCACCACCTATGCAGGTGCGCGGTGGCCGTGATGGGATCATATGGGCC GTCGCCATATTCTGCCCGGGTGTGGTGTTTGACATAACCAAGTGGCTCTTGGCGGTGCTT GGGCCTGCTTATCTCCTAAAAGGTGCTTTGACGCGTGTGCCGTACTTCGTCAGGGCTCAC GCTCTACTAAGGATGTGCACCATGGTAAGGCATCTCGCGGGGGGTAGGTACGTCCAGATG GTGCTACTAGCCCTTGGCAGGTGGACTGGCACTTACATCTATGACCACCTCACCCCTATG TCGGATTGGGCTGCTAATGGCCTGCGGGACTTGGCGGTCGCCGTGGAGCCTATCATCTTC AGTCCGATGGAGAAAAAAGTCATCGTCTGGGGAGCGGAGACAGCTGCTTGCGGGGATATC TTACACGGACTTCCCGTGTCCGCCCGACTTGGCCGGGAGGTCCTCCTTGGCCCAGCTGAT GGCTATACCTCCAAGGGGTGGAGTCTTCTCGCCCCCATCACTGCTTATGCCCAGCAGACA CGCGGCCTTTTGGGCACCATAGTGGTGAGCATGACGGGGCGCGACAAGACAGAACAGGCC GGGGAGATTCAGGTCCTGTCCACGGTCACTCAGTCCTTCCTCGGAACAACCATCTCGGGG GTCTTATGGACTGTCTACCATGGAGCTGGCAACAAGACTCTAGCCGGCTCACGGGGTCCG GTCACACAGATGTACTCCAGTGCTGAGGGGGACTTAGTGGGGTGGCCCAGCCCCCCCGGG ACCAAATCTTTGGAGCCGTGCACGTGTGGAGCGGTCGACCTATACCTGGTCACGCGAAAC GCTGATGTCATCCCGGCTCGAAGACGCGGGGACAAGCGAGGAGCGCTACTCTCCCCGAGA CCTCTTTCCACCTTGAAGGGGTCCTCGGGGGGCCCGGTGCTCTGCCCCAGAGGCCACGCT GTCGGGGTCTTCCGGGCAGCCGTGTGCTCCCGGGGCGTGGCCAAGTCCATAGATTTTATC CCCGTTGAGACACTTGACATCGTCACTCGGTCCCCCACCTTTAGTGACAACAGCACACCA CCTGCTGTGCCCCAAACTTATCAGGTCGGGTACTTACATGCCCCGACTGGTAGTGGAAAG AGCACCAAAGTCCCTGTCGCGTATGCCGCTCAGGGGTACAAAGTGCTAGTGCTTAATCCC TCGGTGGCTGCCACCCTGGGGTTTGGGGCGTACTTGTCCAAGGCACATGGCATCAATCCC AACATTAGGACTGGGGTCAGGACTGTGACGACCGGGGCGCCCATCACGTACTCCACATAT GGCAAATTCCTCGCCGATGGGGGCTGCGCAGGCGGCGCCTATGACATCATCATATGCGAT GAATGCCATGCCGTGGACTCTACCACCATTCTCGGCATCGGAACAGTCCTCGATCAAGCA GAGACAGCCGGGGTCAGGCTAACTGTACTGGCTACGGCTACGCCCCCCGGGTCAGTGACA ACCCCCCACCCCAACATAGAGGAGGTGGCCCTCGGGCAGGAGGGTGAGATCCCCTTCTAT GGGAGGGCGATTCCCCTGTCATACATCAAGGGAGGAAGACACTTGATCTTCTGCCACTCA AAGAAAAAGTGTGACGAGCTCGCGGCGGCCCTTCGGGGTATGGGCTTGAACGCAGTGGCA TACTACAGAGGGCTGGACGTCTCCGTAATACCAACTCAGGGAGACGTAGTGGTCGTCGCC ACCGACGCCCTCATGACGGGGTTTACTGGAGACTTTGACTCCGTGATCGACTGCAACGTA GCGGTCACTCAAGTTGTAGACTTCAGCTTGGACCCCACATTCACCATAACCACACAGACT GTCCCTCAAGACGCTGTCTCACGTAGCCAGCGCCGGGGCCGCACGGGCAGGGGAAGACTG GGTATTTATAGGTATGTTTCCACTGGTGAGCGAGCCTCAGGAATGTTTGACAGTGTAGTG CTCTGCGAGTGCTACGATGCAGGGGCCGCATGGTATGAGCTCACACCAGCGGAGACCACC GTCAGGCTCAGAGCATATTTCAACACACCTGGTTTGCCTGTGTGCCAAGACCATCTTGAG TTTTGGGAGGCAGTTTTCACCGGCCTCACACACATAGATGCCCACTTCCTTTCCCAAACA AAGCAATCGGGGGAAAATTTCGCATACTTAACAGCCTACCAGGCTACAGTGTGCGCTAGG GCCAAAGCCCCCCCCCCGTCCTGGGACGTCATGTGGAAGTGTTTGACTCGACTCAAGCCC ACACTCGTGGGCCCCACACCTCTCCTGTACCGCTTGGGCTCTGTTACCAACGAGGTCACC CTCACGCATCCTGTGACGAAATACATCGCCACCTGCATGCAAGCCGACCTTGAGGTCATG ACCAGCACGTGGGTCTTAGCTGGGGGGGTCTTGGCGGCCGTCGCCGCGTACTGCCTGGCG ACCGGGTGTGTTTGCATCATCGGCCGCTTGCACGTTAACCAGCGAGCCGTCGTTGCACCG GACAAGGAGGTCCTCTATGAGGCTTTTGATGAGATGGAGGAATGTGCCTCTAGAGCGGCT CTCATTGAAGAGGGGCAGCGGATAGCCGAGATGCTGAAGTCCAAGATCCAAGGCTTATTG CAGCAAGCTTCCAAACAAGCTCAAGACATACAACCCGCTGTGCAGGCTTCTTGGCCCAAG GTAGAGCAATTCTGGGCCAAACACATGTGGAACTTCATCAGCGGCATTCAATACCTCGCA GGACTATCAACACTGCCAGGGAACCCTGCTGTAGCTTCCATGATGGCATTCAGTGCCGCC CTCACCAGTCCGTTGTCAACTAGCACCACTATCCTTCTCAACATTTTGGGGGGCTGGCTA GCATCCCAAATTGCGCCTCCCGCGGGGGCTACCGGCTTCGTCGTCAGTGGCCTGGTGGGG GCTGCCGTAGGCAGCATAGGCTTGGGTAAGGTGCTGGTGGACATCCTGGCAGGGTATGGT GCGGGCATTTCGGGGGCTCTCGTCGCATTCAAGATCATGTCTGGCGAGAAGCCCTCCATG GAGGATGTTGTCAACCTGCTGCCTGGAATTCTGTCTCCGGGTGCCCTGGTGGTGGGAGTC ATCTGCGCGGCCATCCTGCGCCGACACGTGGGACCGGGGGAAGGCGCTGTCCAATGGATG AATAGGCTCATTGCCTTTGCTTCCAGAGGAAACCACGTCGCCCCCACCCACTACGTGACG GAGTCGGATGCGTCGCAGCGTGTGACCCAACTACTTGGCTCCCTTACCATAACCAGCCTG CTCAGGAGACTCCACAACTGGATTACTGAAGACTGCCCCATCCCATGCAGCGGCTCGTGG CTCCGCGATGTGTGGGATTGGGTTTGCACCATCCTAACAGACTTTAAAAACTGGCTGACC TCCAAATTGTTCCCAAAGATGCCTGGTCTCCCCTTTATCTCTTGTCAAAAGGGGTACAAG GGCGTGTGGGCTGGCACTGGTATCATGACCACACGGTGTCCTTGCGGCGCCAATATCTCT GGCAATGTCCGCCTGGGCTCCATGAGAATTACGGGGCCCAAAACCTGCATGAATATCTGG CAGGGGACCTTTCCCATCAATTGTTACACGGAGGGCCAGTGCGTGCCGAAACCCGCACCA AACTTTAAGATCGCCATCTGGAGGGTGGCGGCCTCAGAGTACGCGGAGGTGACGCAGCAC GGGTCATACCACTACATAACAGGACTTACCACTGATAACTTGAAAGTTCCTTGCCAACTA CCTTCTCCAGAGTTCTTTTCCTGGGTGGACGGAGTGCAGATCCATAGGTTTGCCCCCATA CCGAAGCCGTTTTTTCGGGATGAGGTCTCGTTCTGCGTTGGGCTTAATTCATTTGTCGTC GGGTCTCAGCTCCCTTGCGATCCTGAACCTGACACAGACGTATTGACGTCCATGCTAACA GACCCATCCCATATCACGGCGGAGACTGCAGCGCGGCGTTTGGCACGGGGGTCACCCCCG TCCGAGGCAAGCTCCTCAGCGAGCCAGCTATCGGCACCATCGCTGCGAGCCACCTGCACC ACCCACGGCAAGGCCTATGATGTGGACATGGTGGATGCCAACCTGTTCATGGGGGGCGAT GTGACCCGGATAGAGTCTGAGTCCAAAGTGGTCGTTCTGGACTCTCTCGACCCAATGGTC GAAGAAAGGAGCGACCTTGAGCCTTCGATACCATCGGAATATATGCTCCCCAAGAAGAGA TTCCCACCAGCCTTACCGGCTTGGGCACGGCCTGATTACAACCCACCGCTTGTGGAATCG TGGAAGAGGCCAGATTACCAACCGGCCACTGTTGCGGGCTGCGCTCTCCCCCCCCCTAAG AAAACCCCGACGCCTCCCCCAAGGAGACGCCGGACAGTGGGTCTGAGTGAGAGCTCCATA GCAGATGCCCTACAACAGCTGGCCATCAAGTCCTTTGGCCAGCCCCCCCCAAGCGGCGAT TCAGGCCTTTCCACGGGGGCGGACGCAGCCGATTCCGGCAGTCGGACGCCCCCCGATGAG TTGGCCCTTTCGGAGACAGGTTCCATCTCCTCCATGCCCCCTCTCGAGGGGGAGCCTGGA GATCCAGACTTGGAGCCTGAGCAGGTAGAGCTTCAACCTCCCCCCCAGGGGGGGGTGGTA ACCCCCGGCTCAGGCTCGGGGTCTTGGTCTACTTGCTCCGAGGAGGACGACTCCGTCGTG TGCTGCTCCATGTCATACTCCTGGACCGGGGCTCTAATAACTCCTTGTAGCCCCGAAGAG GAAAAGTTGCCAATTAACCCCTTGAGCAACTCCCTGTTGCGATATCACAACAAGGTGTAC TGTACCACATCAAAGAGCGCCTCATTAAGGGCTAAAAAGGTAACTTTTGATAGGATGCAA GCGCTCGACGCTCATTATGACTCAGTCTTGAAGGACATTAAGCTAGCGGCCTCCAAGGTC ACCGCAAGGCTTCTCACTTTAGAGGAGGCCTGCCAGTTAACTCCACCCCACTCTGCAAGA TCCAAGTATGGGTTTGGGGCTAAGGAGGTCCGCAGCTTGTCCGGGAGAGCCGTTAACCAC ATCAAGTCCGTGTGGAAGGACCTCCTGGAAGACACACAAACACCAATTCCTACAACCATC ATGGCCAAAAATGAGGTGTTCTGCGTGGACCCCACCAAGGGGGGTAAGAAAGCAGCTCGC CTTATCGTTTACCCTGACCTCGGCGTCAGGGTCTGCGAGAAAATGGCCCTTTATGATATC ACACAAAAGCTTCCTCAGGCGGTGATGGGGGCTTCTTATGGATTCCAGTACTCCCCCGCT CAGCGGGTGGAGTTTCTCTTGAAGGCATGGGCGGAAAAGAAAGACCCTATGGGTTTTTCG TATGATACCCGATGCTTTGACTCAACCGTCACTGAGAGAGACATCAGGACTGAGGAGTCC ATATATCGGGCTTGTTCCTTGCCCGAGGAGGCCCACACTGCCATACACTCACTGACTGAG AGACTTTACGTGGGAGGGCCCATGTTCAACAGCAAGGGCCAGACCTGCGGGTACAGGCGT TGCCGCGCCAGCGGGGTGCTTACCACTAGCATGGGGAACACCATCACATGCTATGTGAAA GCCTTAGCGGCCTGTAAGGCTGCAGGGATAATTGCGCCCACAATGCTGGTATGCGGCGAT GACTTGGTTGTCATCTCAGAGAGCCAGGGGACCGAGGAGGACGAGCGGAACCTGAGAGCC TTCACGGAGGCTATGACCAGGTATTCTGCCCCTCCTGGTGACCCCCCCAGACCGGAATAT GACCTGGAGCTGATAACATCTTGCTCCTCAAATGTGTCTGTGGCGTTGGGCCCACAAGGC CGCCGCAGATACTACCTGACCAGAGACCCTACCACTCCAATCGCCCGGGCTGCCTGGGAA ACAGTTAGACACTCCCCTGTCAATTCATGGCTAGGAAACATCATCCAGTACGCCCCAACC ATATGGGCTCGCATGGTCCTGATGACACACTTCTTCTCCATTCTCATGGCCCAAGATACT CTGGACCAGAACCTCAACTTTGAGATGTACGGAGCGGTGTACTCCGTGAGTCCCTTGGAC CTCCCAGCCATAATTGAAAGGTTACACGGGCTTGACGCTTTCTCTCTGCACACATACACT CCCCACGAACTGACACGGGTGGCTTCAGCCCTCAGAAAACTTGGGGCGCCACCCCTCAGA GCGTGGAAGAGCCGGGCACGTGCAGTCAGGGCGTCCCTCATCTCCCGTGGGGGGAGAGCG GCCGTTTGCGGCCGATATCTCTTCAACTGGGCGGTGAAGACCAAGCTCAAACTCACTCCA TTGCCGGAAGCGCGCCTCCTGGATTTATCCAGCTGGTTCACTGTCGGCGCCGGCGGGGGC GACATTTATCACAGCGTGTCGCGTGCCCGACCCCGCTTATTACTCCTTGGCCTACTCCTA CTTTTTGTAGGGGTAGGCCTTTTCCTACTCCCCGCTCGGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P26660 UniProtKB Entry Name POLG_HCVJ6 GenBank Protein ID 221651 GenBank Gene ID D00944 PDB ID(s) 1YUY, 1YV2, 1YVX, 1YVZ, 2XWH, 4ADP - General References
- Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, Miyakawa Y, Mayumi M: Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions. J Gen Virol. 1991 Nov;72 ( Pt 11):2697-704. [Article]
- Kim CS, Seol SK, Song OK, Park JH, Jang SK: An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. J Virol. 2007 Apr;81(8):3852-65. Epub 2007 Jan 17. [Article]
- Evans MJ, von Hahn T, Tscherne DM, Syder AJ, Panis M, Wolk B, Hatziioannou T, McKeating JA, Bieniasz PD, Rice CM: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature. 2007 Apr 12;446(7137):801-5. Epub 2007 Feb 25. [Article]
- McLauchlan J: Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J Viral Hepat. 2000 Jan;7(1):2-14. [Article]
- Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM: Structural biology of hepatitis C virus. Hepatology. 2004 Jan;39(1):5-19. [Article]
- Biswal BK, Cherney MM, Wang M, Chan L, Yannopoulos CG, Bilimoria D, Nicolas O, Bedard J, James MN: Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem. 2005 May 6;280(18):18202-10. Epub 2005 Mar 2. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 3-[(2,4-Dichlorobenzoyl)(Isopropyl)Amino]-5-Phenylthiophene-2-Carboxylic Acid experimental unknown target Details 3-[Isopropyl(4-Methylbenzoyl)Amino]-5-Phenylthiophene-2-Carboxylic Acid experimental unknown target Details