Lanosterol 14-alpha demethylase CYP51

BE0001730ProteinMycobacterium tuberculosisERG11

Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:105731, PubMed:369554). It is acted on by 6 drugs in DrugBank.

Gene name
ERG11
UniProtKB entry
P10614Swiss-Prot
Cellular location
Membrane
Residues / weight
530 residues · 60,720 Da
Also known as
1.14.13.70 · 1.14.14.154 · CYP51 · CYPLI · Cytochrome P450 51

Resolves to

Protein
UniProtP10614UniProt nameCP51_YEAST
Gene
NCBI Gene856398GenBank1550642
Pharmacology
KEGGsce:YHR007C
Structure
PDB4LXJ
Drugs

What you can answer from here — as of May 03, 2025

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
16+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Lanosterol 14-alpha demethylase CYP51, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In