Biotin synthase

BE0001731ProteinEscherichia coli (strain K12)bioB

Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. It is acted on by 1 drug in DrugBank.

Gene name
bioB
UniProtKB entry
P12996Swiss-Prot
Residues / weight
346 residues · 38,648 Da
Also known as
2.8.1.6 · Biotin synthetase

Resolves to

Protein
UniProtP12996UniProt nameBIOB_ECOLI
Gene
NCBI Gene945370GenBank145425
Pharmacology
KEGGecj:JW0758
Structure
PDB1R30
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Biotin synthase, and which indications are they being tested in?

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