Hyaluronate lyase
Details
- Name
- Hyaluronate lyase
- Kind
- protein
- Synonyms
- 4.2.2.1
- Hyaluronidase
- HYase
- Gene Name
- hylB
- UniProtKB Entry
- Q53591Swiss-Prot
- Organism
- Streptococcus agalactiae serotype III (strain NEM316)
- NCBI Taxonomy ID
- 211110
- Amino acid sequence
>lcl|BSEQ0003442|Hyaluronate lyase MKQVVDNQTQNKELVKNGDFNQTNPVSGSWSHTSAREWSAWIDKENTADKSPIIQRTEQG QVSLSSDKGFRGAVTQKVNIDPTKKYEVKFDIETSNKAGQAFLRIMEKKDNNTRLWLSEM TSGTTNKHTLTKIYNPKLNVSEVTLELYYEKGTGSATFDNISMKAKGPKDSEHPQPVTTQ IEESVNTALNKNYVFNKADYQYTLTNPSLGKIVGGILYPNATGSTTVKISDKSGKIIKEV PLSVTASTEDKFTKLLDKWNDVTIGNHVYDTNDSNMQKINQKLDETNAKNIKTIKLDSNH TFLWKDLDNLNNSAQLTATYRRLEDLAKQITNPHSTIYKNEKAIRTVKESLAWLHQNFYN VNKDIEGSANWWDFEIGVPRSITATLALMNNYFTDAEIKTYTDPIEHFVPDAGYFRKTLD NPFKALGGNLVDMGRVKIIEGLLRKDNTIIEKTSHSLKNLFTTATKAEGFYADGSYIDHT NVAYTGAYGNVLIDGLTQLLPIIQETDYKISNQELDMVYKWINQSFLPLIVKGELMDMSR GRSISREAASSHAAAVEVLRGFLRLANMSNEERNLDLKSTIKTIITSNKFYNVFNNLKSY SDIANMNKMLNDSTVATKPLKSNLSTFNSMDRLAYYNAEKDFGFALSLHSKRTLNYEGMN DENTRDWYTGDGMFYLYNSDQSHYSNHFWPTVNPYKMAGTTEKDAKREDTTKEFMSKHSK DAKEKTGQVTGTSDFVGSVKLNDHFALAAMDFTNWDRTLTAQKGWVILNDKIVFLGSNIK NTNGIGNVSTTIDQRKDDSKTPYTTYVNGKTIDLKQASSQQFTDTKSVFLESKEPGRNIG YIFFKNSTIDIERKEQTGTWNSINRTSKNTSIVSNPFITISQKHDNKGDSYGYMMVPNID RTSFDKLANSKEVELLENSSKQQVIYDKNSQTWAVIKHDNQESLINNQFKMNKAGLYLVQ KVGNDYQNVYYQPQTMTKTDQLAI
- Number of residues
- 984
- Molecular Weight
- 111580.345
- Theoretical pI
- 8.99
- GO Classification
- Functionscarbohydrate binding / hyaluronate lyase activityProcessescarbohydrate metabolic processComponentsextracellular region
- General Function
- Not Available
- Specific Function
- carbohydrate binding
- Pfam Domain Function
- Signal Regions
- 1-40
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0003441|2955 bp ATGAAACAAGTAGTAGATAATCAAACTCAAAATAAGGAGCTGGTGAAAAACGGAGATTTT AATCAAACTAACCCTGTATCTGGAAGCTGGTCACATACAAGCGCTAGGGAATGGTCTGCT TGGATTGATAAAGGAAATACTGCTGATAAATCACCTATTATCCAACGTACCGAACAAGGC CAAGTAAGTCTATCCAGCGACAAAGGCTTTAGAGGTGCTGTAACACAAAAAGTGAACATT GATCCCACTAAAAAATATGAGGTTAAGTTTGATATTGAAACAAGTAACAAGGCTGGACAA GCTTTCCTTCGTATTATGGAGAAAAAAGACAACAATACGCGACTTTGGCTTTCTGAGATG ACCAGCGGTACTACTAACAAACATACCTTAACAAAGATATATAACCCAAAGTTAAATGTC TCCGAGGTGACACTTGAACTTTATTATGAAAAAGGAACTGGTTTTGTTACTTTTGATAAT ATATCAATGAAAGCAAAAGGCCCTAAAGACTCAGAGCATCCACAACCCGTCACAACACAA ATTGAAAAAAGCGTTAATACGGCTTTAAACAAAAATTACGTTTTTAATAAAGCTGACTAC CAATACACTCTAACCAATCCGTCTCTTGGGAAAATTGTTGGGGGAATATTGTATCCAAAC GCTACTGGTTCAACAACTGTTAAAATATCTGATAAATCTGGGAAAATAATTAAAGAAGTA CCGTTATCAGTTACAGGTTCACCAGAAGATAACTTTACAAAACTCCTCGACAAATGGAAC GACGTGACTATTGGTAATTATGTTTACGATACTAATGATTCGAACATGCAAAAGCTTACT CAGAAATTAGATGAAACTAACGGCAAAAACATCGAAGCTATCAAACTGGATTCTAATCGC ACTTTCCTTTGGAAAGATTTAGATAATCTCAATAATTCAGCACAGTTAACCGCTACTTAT CGTCGTTTGGAAGATTTAGCTAAACAAATCACCAATCCACACTCTACTATTTACAAAAAT GAAAAAGCTATTCGTACTGTAAAAGAGAGTCTGGCTTGGCTTCATCAGAACTTCTACAAT GTTAATAAAGATATAGAAGGCTCTGCCAATTGGTGGGATTTTGAAATCGGTGTTCCTCGC TCAATTACAGGTACCCTATCTCTCATGAATAACTACTTCACTGACGCTGAAATAAAAACT TATACCGACCCAATTGAACACTTTGTTCCTGATGCAGAATATTTCCGTAAAACGCTTGTC AATCCATTTAAAGCCCTTGGTGGTAATCTAGTAGATATGGGGCGCGTTAAAATCATTGAA GGTTTACTTCGTAAAGACAATACTATTATCGAAAAAACTTCTCATTCTCTAAAAAATCTT TTTACTACTGCTACTAAAGCTGAAGGCTTCTATGCTGACGGTTCTTACATCGACCATACA AATGTTGCTTATACTGGCGCCTATGGTAATGTTCTGATAGATGGTTTGACACAATTGCTG CCTATCATTCAAGAAACTGACTATAAAATCTCTAATCAAGAACTTGATATGGTTTATAAA TGGATTAATCAATCATTTTTACCTTTAATTGTAAAAGGTGAGTTAATGGATATGAGTCGT GGACGCTCAATTAGTAGAGAGGCAGCTTCTTCGCATGCGGCTGCAGTTGAAGTTCTCAGA GGTTTCCTCAGATTGGCTAACATGTCTAATGAAGAGCGAAACTTAGACCTCAAATCAACT ATTAAAGCGATTATCACTTCAAATAAATTCTACAATGTCTTCAATAACCTCAAATCGTAT TCCGATATTGCCAACATGAATAAGCTGCTTAATGACAGTACAGTCGCTACTAAACCTTTA AAAAGTAATTTATCAACCTTTAATAGCATGGACCGCTTAGCTTATTATAATGCCAAGAAA GACTTTGGTTTCGCGCTTTCATTACATTCTAAACGTACCCTCAACTATGAAGGAATGAAT GATGAAAATACACGTGGTTGGTATACCGGAGATGGTATGTTCTATATTTATAATAGTGAT CAATCTCATTATAGTAATCATTTGGGGCCAACCGTCAATCCTTATAAAATGGCTGGAACA ACTGAAAAAGATGCTAAGCGTGAAGATACCACTAAGGAATTCATGAGCAAACATAGCAAA GACGCTAAAGAAAAAACCGGTCAAGTTACAGGAACATCTGACTTTGTTGGTTCCGTCAAA CTTAATGATCACTTTGCTCTTGCCGCTATGGATTTTACTAACTGGGATCGCACCTTAACA GCACAAAAAGGTTGGGTTATCTTAAATGATAAGATTGTCTTTTTAGGTAGCAACATCAAG AATACTAACGGCATTGGAAATGTTTCTACAACAATTGATCAACGAAAAGACGATTCTAAA ACACCTTATACTACATACGTCAATGGAAAAACTATTGATTTAAAACAAGCAAGTTCTCAA CAATTTACAGATACAAAAAGTGTCTTTTTAGAATCAAAAGAACCTGGTCGCAATATTGGT TATATCTTCTTTAAAAATAGCACTATTGATATTGAACGCAAAGAGCAAACAGGTACTTGG AACAGCATTAATCGTACTTCTAAAAATACCTCAATCGTTAGCAATCCTTTTATCACTATA AGCCTTAAGCATGACAACAAAGGTGATAGCTATGGTTACCTGATGGTTCCAAACATTGAT CGCACTAGTTTTGATAAATTAGCCAACAGCAAAGAAGTAGAATTACTAGAAAATAGTTCA AAACAACAAGTTATCTATGATAAAAACAGTCAAACTTGGGCTGTTATCAAACACGATAAT CAAGAGAGTCTCATTAACAATCAATTCAAAATGAATAAAGCGGGACTTTACCTAGTACAA AAAGTTGGTAATGACTATCAAAATGTCTATTACCAACCTCAAACCATGACAAAAACAGAC CAATTAGCTATCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q53591 UniProtKB Entry Name HYSA_STRA3 GenBank Protein ID 595847 GenBank Gene ID U15050 PDB ID(s) 1F1S, 1I8Q, 1LXM - General References
- Lin B, Hollingshead SK, Coligan JE, Egan ML, Baker JR, Pritchard DG: Cloning and expression of the gene for group B streptococcal hyaluronate lyase. J Biol Chem. 1994 Dec 2;269(48):30113-6. [Article]
- Glaser P, Rusniok C, Buchrieser C, Chevalier F, Frangeul L, Msadek T, Zouine M, Couve E, Lalioui L, Poyart C, Trieu-Cuot P, Kunst F: Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease. Mol Microbiol. 2002 Sep;45(6):1499-513. [Article]
- Li S, Jedrzejas MJ: Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase. J Biol Chem. 2001 Nov 2;276(44):41407-16. Epub 2001 Aug 29. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 4-Deoxy-D-Glucuronic Acid experimental unknown target Details