dTDP-glucose 4,6-dehydratase

BE0001740ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)rfbB

Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. It is acted on by 1 drug in DrugBank.

Gene name
rfbB
UniProtKB entry
P26391Swiss-Prot
Residues / weight
361 residues · 40,718 Da
Also known as
4.2.1.46

Resolves to

Protein
UniProtP26391UniProt nameRMLB_SALTY
Gene
NCBI Gene1253618GenBank581654
Pharmacology
KEGGstm:STM2097
Structure
PDB1G1APDB1KEUPDB1KEW
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on dTDP-glucose 4,6-dehydratase, and which indications are they being tested in?

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