2-isopropylmalate synthase

BE0001742ProteinMycobacterium tuberculosisleuA

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (alpha-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (PubMed:11914056, PubMed:16846242). It is acted on by 1 drug in DrugBank.

Gene name
leuA
UniProtKB entry
P9WQB3Swiss-Prot
Residues / weight
644 residues · 70,113 Da
Also known as
2.3.3.13 · Alpha-IPM synthase · Alpha-isopropylmalate synthase

Resolves to

Protein
UniProtP9WQB3UniProt nameLEU1_MYCTU
Gene
NCBI Gene885092
Pharmacology
KEGGmtu:Rv3710
Structure
PDB1SR9PDB3FIGPDB3HPS
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-isopropylmalate synthase, and which indications are they being tested in?

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