Bifunctional enzyme IspD/IspF

BE0001748ProteinCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)ispDF

Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)... It is acted on by 2 drugs in DrugBank.

Gene name
ispDF
UniProtKB entry
Q9PM68Swiss-Prot
Residues / weight
371 residues · 41,690 Da
Also known as
2.7.7.60 · MECDP-synthase

Resolves to

Protein
UniProtQ9PM68UniProt nameISPDF_CAMJE
Gene
NCBI Gene905874GenBank112360903
Pharmacology
KEGGcje:Cj1607
Structure
PDB1W55PDB1W57
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bifunctional enzyme IspD/IspF, and which indications are they being tested in?

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