Porphobilinogen deaminase

BE0001758ProteinEscherichia coli (strain K12)hemC

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. It is acted on by 1 drug in DrugBank.

Gene name
hemC
UniProtKB entry
P06983Swiss-Prot
Residues / weight
313 residues · 33,851 Da
Also known as
2.5.1.61 · HMBS · Hydroxymethylbilane synthase · PBG · popE

Resolves to

Protein
UniProtP06983UniProt nameHEM3_ECOLI
Gene
NCBI Gene947759GenBank41664
Pharmacology
KEGGecj:JW5932
Structure
PDB1AH5PDB1GTKPDB1PDA
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Porphobilinogen deaminase, and which indications are they being tested in?

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