3-phosphoshikimate 1-carboxyvinyltransferase
Details
- Name
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Kind
- protein
- Synonyms
- 2.5.1.19
- 5-enolpyruvylshikimate-3-phosphate synthase
- EPSP synthase
- EPSPS
- Gene Name
- aroA
- UniProtKB Entry
- Q9S400Swiss-Prot
- Organism
- Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
- NCBI Taxonomy ID
- 170187
- Amino acid sequence
>lcl|BSEQ0011255|3-phosphoshikimate 1-carboxyvinyltransferase MKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLSTMQVFRDLGV EIEDKDGVITIQGVGMAGLKAPQNALNMGNSGTSIRLISGVLAGADFEVEMFGDDSLSKR PMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHYELPIASAQVKSALMFAALQA KGESVIIEKEYTRNHTEDMLKQFGGHLSVDGKKITVQGPQKLTGQKVVVPGDISSAAFWL VAGLIAPNSRLVLQNVGINETRTGIIDVIRAMGGKLEITEIDPVAKSATLIVESSDLKGT EIGGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADALNSMGADITP TADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADGEVELDRAEAINTSYPSFFDD LESLIHG
- Number of residues
- 427
- Molecular Weight
- 45765.42
- Theoretical pI
- 6.07
- GO Classification
- Functions3-phosphoshikimate 1-carboxyvinyltransferase activityProcessesaromatic amino acid family biosynthetic process / chorismate biosynthetic processComponentscytoplasm
- General Function
- Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
- Specific Function
- 3-dehydroquinate dehydratase activity
- Pfam Domain Function
- EPSP_synthase (PF00275)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011256|3-phosphoshikimate 1-carboxyvinyltransferase (aroA) ATGAAACTAAAAACAAACATTCGCCATTTACATGGTAGTATCCGCGTCCCAGGTGACAAG TCTATCAGCCACCGTTCCATTATCTTTGGAAGTTTGGCTGAGGGTGAGACCAAGGTTTAT GATATTCTGCGAGGTGAAGACGTTCTTTCGACCATGCAGGTTTTTCGTGACCTTGGTGTT GAAATTGAGGATAAAGATGGGGTTATTACCATTCAAGGTGTAGGCATGGCTGGCTTAAAA GCGCCACAAAATGCCCTTAATATGGGAAATTCTGGCACCTCGATTCGCCTGATTTCAGGT GTCCTTGCTGGTGCAGATTTCGAAGTAGAGATGTTTGGAGATGATAGTCTTTCCAAACGT CCTATGGACCGTGTGACCCTTCCACTGAAAAAAATGGGCGTCAGCATTTCAGGGCAAACT GAACGAGACTTGCCTCCCCTTCGCTTAAAAGGGACGAAAAACCTAAGACCTATTCATTAT GAGTTGCCAATTGCCTCTGCCCAAGTCAAGTCAGCCTTGATGTTTGCAGCCTTACAAGCT AAGGGGGAGTCAGTTATTATCGAAAAAGAGTACACCCGTAATCATACTGAAGATATGTTG AAACAATTTGGTGGTCATTTAAGTGTGGATGGTAAGAAAATCACAGTCCAGGGGCCACAA AAATTGACAGGACAGAAGGTGGTCGTACCAGGAGATATTTCCAGTGCAGCCTTTTGGTTA GTCGCAGGTTTGATTGCTCCAAATTCTCGTCTAGTGCTGCAGAATGTGGGGATCAACGAA ACTCGCACCGGTATTATTGATGTCATTCGTGCCATGGGTGGAAAATTGGAAATAACTGAA ATCGATCCAGTCGCTAAATCTGCTACCTTGATTGTTGAGTCTTCTGACTTGAAAGGAACA GAGATTGGTGGCGCTTTGATTCCACGATTGATTGATGAATTGCCCATTATTGCCCTGCTT GCGACCCAAGCCCAAGGTGTAACAGTTATCAAGGATGCTGAGGAGCTCAAGGTCAAGGAA ACAGACCGTATTCAGGTTGTGGCAGACGCCTTAAATAGTATGGGAGCAGATATTACTCCT ACGGCAGATGGGATGATTATCAAAGGAAAATCAGCTCTTCACGGTGCTAGAGTCAATACG TTTGGTGACCACCGTATCGGCATGATGACAGCTATCGCAGCCCTCTTGGTTGCAGATGGA GAGGTGGAGCTTGACCGTGCAGAAGCCATCAATACCAGCTATCCTAGTTTCTTTGATGAT TTGGAGAGCTTGATTCATGGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9S400 UniProtKB Entry Name AROA_STRPN GenBank Protein ID 5616525 GenBank Gene ID AF169483 PDB ID(s) 1RF4, 1RF5, 1RF6 KEGG ID spn:SP_1371 - General References
- Du W, Wallis NG, Mazzulla MJ, Chalker AF, Zhang L, Liu WS, Kallender H, Payne DJ: Characterization of Streptococcus pneumoniae 5-enolpyruvylshikimate 3-phosphate synthase and its activation by univalent cations. Eur J Biochem. 2000 Jan;267(1):222-7. [Article]
- Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]
- Park H, Hilsenbeck JL, Kim HJ, Shuttleworth WA, Park YH, Evans JN, Kang C: Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state. Mol Microbiol. 2004 Feb;51(4):963-71. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Shikimate-3-Phosphate experimental unknown target Details Glyphosate experimental unknown target inhibitor Details