3-phosphoshikimate 1-carboxyvinyltransferase

BE0001759ProteinStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)aroA

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. It is acted on by 2 drugs in DrugBank.

Gene name
aroA
UniProtKB entry
Q9S400Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
427 residues · 45,765 Da
Also known as
2.5.1.19 · 5-enolpyruvylshikimate-3-phosphate synthase · EPSP synthase · EPSPS

Resolves to

Protein
UniProtQ9S400UniProt nameAROA_STRPN
Gene
GenBank5616525
Pharmacology
KEGGspn:SP_1371
Structure
PDB1RF4PDB1RF5PDB1RF6
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-phosphoshikimate 1-carboxyvinyltransferase, and which indications are they being tested in?

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