NH(3)-dependent NAD(+) synthetase
Details
- Name
- NH(3)-dependent NAD(+) synthetase
- Kind
- protein
- Synonyms
- 6.3.1.5
- Gene Name
- nadE
- UniProtKB Entry
- O25096Swiss-Prot
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- NCBI Taxonomy ID
- 85962
- Amino acid sequence
>lcl|BSEQ0011262|NH(3)-dependent NAD(+) synthetase MQKDYQKLIVYLCDFLEKEVQKRGFKKVVYGLSGGLDSAVVGVLCQKVFKENAHALLMPS SVSMPENKTDALNLCEKFSIPYTEYSIAPYDAIFSSHFKDASLTRKGNFCARLRMAFLYD YSLKSDSLVIGTSNKSERMLGYGTLFGDLACAINPIGELFKTEVYELARRLNIPKKILNK PPSADLFVGQSDEKDLGYPYSVIDPLLKDIEALFQTKPIDTETLAQLGYDEILVKNITSR IQKNAFKLELPAIAKRFNPE
- Number of residues
- 260
- Molecular Weight
- 29268.575
- Theoretical pI
- 8.16
- GO Classification
- FunctionsATP binding / NAD+ synthase (glutamine-hydrolyzing) activity / NAD+ synthase activityProcessesNAD biosynthetic process
- General Function
- Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
- Specific Function
- ATP binding
- Pfam Domain Function
- NAD_synthase (PF02540)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011263|NH(3)-dependent NAD(+) synthetase (nadE) ATGCAAAAAGATTACCAAAAACTCATCGTTTATTTATGCGATTTTTTAGAAAAAGAAGTG CAAAAACGCGGCTTTAAAAAAGTCGTTTACGGGCTGAGCGGGGGGCTAGATAGCGCGGTC GTTGGGGTGCTGTGTCAAAAAGTTTTTAAAGAAAACGCTCATGCCCTTTTAATGCCCTCT TCAGTCTCTATGCCAGAAAATAAAACAGACGCCCTAAATTTGTGCGAAAAATTTTCTATC CCTTATACAGAATATTCTATCGCTCCCTATGACGCCATCTTTAGCTCTCACTTTAAAGAC GCAAGCCTTACTAGGAAGGGGAATTTTTGCGCAAGATTGCGCATGGCTTTTTTATACGAT TATTCTTTAAAAAGCGATTCTTTAGTCATTGGCACGAGCAATAAAAGCGAAAGAATGCTA GGCTATGGCACTTTATTTGGGGATTTGGCGTGCGCGATTAACCCGATTGGGGAATTATTT AAAACCGAAGTTTATGAACTCGCTCGCCGTTTAAATATCCCTAAAAAGATTTTAAATAAG CCCCCTAGCGCAGATTTATTTGTGGGGCAAAGCGATGAAAAAGATTTGGGCTATCCTTAT AGCGTGATCGATCCTTTATTGAAGGATATTGAAGCGTTGTTTCAAACAAAGCCCATTGAT ACAGAAACGCTCGCTCAATTAGGCTATGATGAAATTTTAGTGAAAAACATCACAAGCCGT ATCCAAAAAAACGCTTTTAAATTAGAATTACCCGCCATCGCCAAACGATTTAACCCTGAA TGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O25096 UniProtKB Entry Name NADE_HELPY GenBank Protein ID 2313426 GenBank Gene ID AE000511 PDB ID(s) 1XNG, 1XNH KEGG ID heo:C694_01665 NCBI Gene ID 900366 - General References
- Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Deamido-Nad+ experimental unknown target Details