Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

BE0001774ProteinHelicobacter pylori (strain ATCC 700392 / 26695)fabI

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It is acted on by 2 drugs in DrugBank.

Gene name
fabI
UniProtKB entry
O24990Swiss-Prot
Cellular location
Cell inner membrane; peripheral membrane protein
Residues / weight
275 residues · 29,981 Da
Also known as
1.3.1.9 · ENR · NADH-dependent enoyl-ACP reductase

Resolves to

Protein
UniProtO24990UniProt nameFABI_HELPY
Gene
NCBI Gene899156GenBank2313282
Pharmacology
KEGGheo:C694_00970
Structure
PDB2PD3PDB2PD4
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3GO termsFunction, process and component, as structured annotations
Sign in
4+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In