Bifunctional polymyxin resistance protein ArnA

BE0001788ProteinEscherichia coli (strain K12)arnA

Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). It is acted on by 2 drugs in DrugBank.

Gene name
arnA
UniProtKB entry
P77398Swiss-Prot
Residues / weight
660 residues · 74,288 Da
Also known as
pmrI · Polymyxin resistance protein PmrI · yfbG

Resolves to

Protein
UniProtP77398UniProt nameARNA_ECOLI
Gene
NCBI Gene947683GenBank16555376
Pharmacology
KEGGecj:JW2249
Structure
PDB1U9JPDB1YRWPDB1Z73
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bifunctional polymyxin resistance protein ArnA, and which indications are they being tested in?

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