6,7-dimethyl-8-ribityllumazine synthase 2
Details
- Name
- 6,7-dimethyl-8-ribityllumazine synthase 2
- Kind
- protein
- Synonyms
- 2.5.1.78
- DMRL synthase 2
- ribH-2
- Gene Name
- ribH2
- UniProtKB Entry
- P61713Swiss-Prot
- Organism
- Brucella suis biovar 1 (strain 1330)
- NCBI Taxonomy ID
- 204722
- Amino acid sequence
>lcl|BSEQ0011280|6,7-dimethyl-8-ribityllumazine synthase 2 MNQSCPNKTSFKIAFIQARWHADIVDEARKSFVAELAAKTGGSVEVEIFDVPGAYEIPLH AKTLARTGRYAAIVGAAFVIDGGIYRHDFVATAVINGMMQVQLETEVPVLSVVLTPHHFH ESKEHHDFFHAHFKVKGVEAAHAALQIVSERSRIAALV
- Number of residues
- 158
- Molecular Weight
- 17355.785
- Theoretical pI
- 7.14
- GO Classification
- Functions6,7-dimethyl-8-ribityllumazine synthase activity / transferase activityProcessesriboflavin biosynthetic processComponentsriboflavin synthase complex
- General Function
- Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
- Specific Function
- 6,7-dimethyl-8-ribityllumazine synthase activity
- Pfam Domain Function
- DMRL_synthase (PF00885)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011281|6,7-dimethyl-8-ribityllumazine synthase 2 (ribH2) ATGAACCAAAGCTGTCCGAACAAGACATCCTTTAAAATCGCATTCATTCAGGCCCGCTGG CACGCCGACATCGTTGACGAAGCGCGCAAAAGCTTTGTCGCCGAACTGGCCGCAAAGACA GGTGGCAGCGTCGAGGTAGAGATATTCGACGTGCCGGGTGCATATGAAATTCCCCTTCAC GCCAAGACATTGGCCAGAACCGGGCGCTATGCAGCCATCGTCGGTGCGGCCTTCGTGATC GACGGCGGCATCTATCGTCATGATTTCGTGGCGACGGCCGTTATCAACGGCATGATGCAG GTGCAGCTTGAAACGGAAGTGCCGGTGCTGAGCGTCGTGCTGACGCCGCACCATTTCCAT GAAAGCAAGGAGCATCACGACTTCTTCCATGCTCATTTCAAGGTGAAGGGCGTGGAAGCG GCCCATGCCGCCTTGCAGATCGTGAGCGAGCGCAGCCGCATCGCCGCGCTTGTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P61713 UniProtKB Entry Name RISB2_BRUSU GenBank Protein ID 23464060 GenBank Gene ID AE014292 KEGG ID bms:BRA0695 NCBI Gene ID 23672548 - General References
- Paulsen IT, Seshadri R, Nelson KE, Eisen JA, Heidelberg JF, Read TD, Dodson RJ, Umayam L, Brinkac LM, Beanan MJ, Daugherty SC, Deboy RT, Durkin AS, Kolonay JF, Madupu R, Nelson WC, Ayodeji B, Kraul M, Shetty J, Malek J, Van Aken SE, Riedmuller S, Tettelin H, Gill SR, White O, Salzberg SL, Hoover DL, Lindler LE, Halling SM, Boyle SM, Fraser CM: The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13148-53. Epub 2002 Sep 23. [Article]
- Tae H, Shallom S, Settlage R, Preston D, Adams LG, Garner HR: Revised genome sequence of Brucella suis 1330. J Bacteriol. 2011 Nov;193(22):6410. doi: 10.1128/JB.06181-11. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 5-Nitro-6-ribityl-amino-2,4(1H,3H)-pyrimidinedione experimental unknown target Details