6,7-dimethyl-8-ribityllumazine synthase 2

Details

Name
6,7-dimethyl-8-ribityllumazine synthase 2
Kind
protein
Synonyms
  • 2.5.1.78
  • DMRL synthase 2
  • ribH-2
Gene Name
ribH2
UniProtKB Entry
P61713Swiss-Prot
Organism
Brucella suis biovar 1 (strain 1330)
NCBI Taxonomy ID
204722
Amino acid sequence
>lcl|BSEQ0011280|6,7-dimethyl-8-ribityllumazine synthase 2
MNQSCPNKTSFKIAFIQARWHADIVDEARKSFVAELAAKTGGSVEVEIFDVPGAYEIPLH
AKTLARTGRYAAIVGAAFVIDGGIYRHDFVATAVINGMMQVQLETEVPVLSVVLTPHHFH
ESKEHHDFFHAHFKVKGVEAAHAALQIVSERSRIAALV
Number of residues
158
Molecular Weight
17355.785
Theoretical pI
7.14
GO Classification
Functions
6,7-dimethyl-8-ribityllumazine synthase activity / transferase activity
Processes
riboflavin biosynthetic process
Components
riboflavin synthase complex
General Function
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Specific Function
6,7-dimethyl-8-ribityllumazine synthase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011281|6,7-dimethyl-8-ribityllumazine synthase 2 (ribH2)
ATGAACCAAAGCTGTCCGAACAAGACATCCTTTAAAATCGCATTCATTCAGGCCCGCTGG
CACGCCGACATCGTTGACGAAGCGCGCAAAAGCTTTGTCGCCGAACTGGCCGCAAAGACA
GGTGGCAGCGTCGAGGTAGAGATATTCGACGTGCCGGGTGCATATGAAATTCCCCTTCAC
GCCAAGACATTGGCCAGAACCGGGCGCTATGCAGCCATCGTCGGTGCGGCCTTCGTGATC
GACGGCGGCATCTATCGTCATGATTTCGTGGCGACGGCCGTTATCAACGGCATGATGCAG
GTGCAGCTTGAAACGGAAGTGCCGGTGCTGAGCGTCGTGCTGACGCCGCACCATTTCCAT
GAAAGCAAGGAGCATCACGACTTCTTCCATGCTCATTTCAAGGTGAAGGGCGTGGAAGCG
GCCCATGCCGCCTTGCAGATCGTGAGCGAGCGCAGCCGCATCGCCGCGCTTGTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP61713
UniProtKB Entry NameRISB2_BRUSU
GenBank Protein ID23464060
GenBank Gene IDAE014292
KEGG IDbms:BRA0695
NCBI Gene ID23672548
General References
  1. Paulsen IT, Seshadri R, Nelson KE, Eisen JA, Heidelberg JF, Read TD, Dodson RJ, Umayam L, Brinkac LM, Beanan MJ, Daugherty SC, Deboy RT, Durkin AS, Kolonay JF, Madupu R, Nelson WC, Ayodeji B, Kraul M, Shetty J, Malek J, Van Aken SE, Riedmuller S, Tettelin H, Gill SR, White O, Salzberg SL, Hoover DL, Lindler LE, Halling SM, Boyle SM, Fraser CM: The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13148-53. Epub 2002 Sep 23. [Article]
  2. Tae H, Shallom S, Settlage R, Preston D, Adams LG, Garner HR: Revised genome sequence of Brucella suis 1330. J Bacteriol. 2011 Nov;193(22):6410. doi: 10.1128/JB.06181-11. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
5-Nitro-6-ribityl-amino-2,4(1H,3H)-pyrimidinedioneexperimentalunknowntargetDetails