8-amino-7-oxononanoate synthase

BE0001794ProteinEscherichia coli (strain K12)bioF

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. It is acted on by 2 drugs in DrugBank.

Gene name
bioF
UniProtKB entry
P12998Swiss-Prot
Residues / weight
384 residues · 41,594 Da
Also known as
2.3.1.47 · 7-KAP synthase · 7-keto-8-amino-pelargonic acid synthase · 8-amino-7-ketopelargonate synthase · AONS

Resolves to

Protein
UniProtP12998UniProt nameBIOF_ECOLI
Gene
NCBI Gene945384
Pharmacology
KEGGecj:JW0759
Structure
PDB1BS0PDB1DJ9PDB1DJE
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 8-amino-7-oxononanoate synthase, and which indications are they being tested in?

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