Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

BE0001809ProteinHumansNMNAT1

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). It is acted on by 2 drugs in DrugBank.

Gene name
NMNAT1
UniProtKB entry
Q9HAN9Swiss-Prot
Cellular location
Nucleus
Residues / weight
279 residues · 31,932 Da
Also known as
2.7.7.1 · 2.7.7.18 · NaMN adenylyltransferase 1 · Nicotinamide-nucleotide adenylyltransferase 1 · Nicotinate-nucleotide adenylyltransferase 1

Resolves to

Protein
UniProtQ9HAN9UniProt nameNMNA1_HUMAN
Gene
HGNCHGNC:17877NCBI Gene64802GenBank11245478GeneCardsNMNAT1
Pharmacology
KEGGhsa:64802
Structure
PDB1GZUPDB1KKUPDB1KQN
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, and which indications are they being tested in?

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