DNA helicase/primase

BE0001811ProteinEnterobacteria phage T7

ATP-dependent DNA helicase and primase essential for viral DNA replication and recombination (PubMed:21606333, PubMed:22977246, PubMed:32009150). It is acted on by 2 drugs in DrugBank.

UniProtKB entry
P03692Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
566 residues · 62,655 Da
Also known as
2.7.7.- · DNA 3'-5' helicase/primase Gp4 · DNA primase/helicase · Gene product 4 · Gp4

Resolves to

Protein
UniProtP03692UniProt nameHELIC_BPT7
Gene
NCBI Gene1261046GenBank15519
Pharmacology
KEGGvg:1261046
Structure
PDB1CR0PDB1CR1PDB1CR2
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA helicase/primase, and which indications are they being tested in?

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