Multidrug efflux pump subunit AcrB

BE0001817ProteinEscherichia coli (strain K12)acrB

AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. It is acted on by 3 drugs in DrugBank.

Gene name
acrB
UniProtKB entry
P31224Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
1,049 residues · 113,573 Da
Also known as
AcrAB-TolC multidrug efflux pump subunit AcrB · acrE · Acridine resistance protein B

Resolves to

Protein
UniProtP31224UniProt nameACRB_ECOLI
Gene
NCBI Gene945108GenBank290406
Pharmacology
KEGGecj:JW0451
Structure
PDB1IWGPDB1OY6PDB1OY8
Drugs

What you can answer from here — as of September 04, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Multidrug efflux pump subunit AcrB, how selective are they, and which programs against it are still in active trials?

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