ATP-dependent 6-phosphofructokinase

BE0001818ProteinGeobacillus stearothermophiluspfkA

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. It is acted on by 3 drugs in DrugBank.

Gene name
pfkA
UniProtKB entry
P00512Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
319 residues · 34,119 Da
Also known as
2.7.1.11 · ATP-PFK · pfk · Phosphohexokinase

Resolves to

Protein
UniProtP00512UniProt namePFKA_GEOSE
Gene
GenBank143312
Structure
PDB1MTOPDB3PFKPDB3U39
Drugs

What you can answer from here — as of September 04, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Metabolic reactionDrug transformations it catalyses, substrate to product
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
15+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on ATP-dependent 6-phosphofructokinase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In