3-methyl-2-oxobutanoate hydroxymethyltransferase

BE0001822ProteinNeisseria meningitidis serogroup B (strain MC58)panB

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. It is acted on by 1 drug in DrugBank.

Gene name
panB
UniProtKB entry
Q9JZW6Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
263 residues · 27,739 Da
Also known as
2.1.2.11 · Ketopantoate hydroxymethyltransferase · KPHMT

Resolves to

Protein
UniProtQ9JZW6UniProt namePANB_NEIMB
Gene
NCBI Gene902986GenBank7226107
Pharmacology
KEGGnme:NMB0870
Structure
PDB1O66PDB1O68
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-methyl-2-oxobutanoate hydroxymethyltransferase, and which indications are they being tested in?

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