Hydroxyacylglutathione hydrolase, mitochondrial

BE0001825ProteinHumansHAGH

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. It is acted on by 2 drugs in DrugBank.

Gene name
HAGH
UniProtKB entry
Q16775Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
308 residues · 33,806 Da
Also known as
3.1.2.6 · GLO2 · Glx II · Glyoxalase II · HAGH1

Resolves to

Protein
UniProtQ16775UniProt nameGLO2_HUMAN
Gene
HGNCHGNC:4805NCBI Gene3029GenBank1237213GeneCardsHAGH
Pharmacology
KEGGhsa:3029
Structure
PDB1QH3PDB1QH5
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hydroxyacylglutathione hydrolase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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