Caspase-7

BE0001826ProteinHumansCASP7

Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). It is acted on by 4 drugs in DrugBank.

Gene name
CASP7
UniProtKB entry
P55210Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
303 residues · 34,276 Da
Also known as
3.4.22.60 · Apoptotic protease Mch-3 · CASP-7 · CMH-1 · ICE-LAP3

Resolves to

Protein
UniProtP55210UniProt nameCASP7_HUMAN
Gene
HGNCHGNC:1508NCBI Gene840GenBank1125073GeneCardsCASP7
Pharmacology
IUPHAR/GtoPdb1623KEGGhsa:840
Structure
PDB1F1JPDB1GQFPDB1I4O
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Caspase-7, and which indications are they being tested in?

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