Cell division control protein 2 homolog
Details
- Name
- Cell division control protein 2 homolog
- Kind
- protein
- Synonyms
- 2.7.11.22
- PfPK5
- PK5
- Gene Name
- CRK2
- UniProtKB Entry
- Q07785Swiss-Prot
- Organism
- Plasmodium falciparum (isolate K1 / Thailand)
- NCBI Taxonomy ID
- 5839
- Amino acid sequence
>lcl|BSEQ0011308|Cell division control protein 2 homolog MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRR VLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYST TIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTV YEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN
- Number of residues
- 288
- Molecular Weight
- 32995.905
- Theoretical pI
- 8.08
- GO Classification
- FunctionsATP binding / cyclin-dependent protein serine/threonine kinase activity / RNA polymerase II carboxy-terminal domain kinase activityComponentscytoplasm
- General Function
- Serine/threonine-protein kinase (PubMed:14604523, PubMed:8844681). Involved in the control of the cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). In schizonts, phosphorylates ORC1 resulting in its dissociation from DNA, relocalization to the cytoplasm and likely its degradation (By similarity).
- Specific Function
- ATP binding
- Pfam Domain Function
- Not Available
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0003619|867 bp ATGGAGAAATATCATGGTTTAGAAAAAATAGGAGAGGGAACATATGGGGTAGTTTACAAA GCCCAAAATAATTATGGTGAAACTTTTGCCTTAAAAAAAATTAGATTAGAAAAAGAAGAT GAAGGAATTCCATCAACAACAATAAGAGAGATTAGCATTTTGAAGGAATTGAAACATTCC AACATAGTAAAGTTGTATGATGTCATACACACAAAGAAAAGATTAGTTTTAGTTTTTGAG CATCTTGATCAAGATCTTAAGAAACTTCTGGATGTTTGTGAAGGAGGGTTGGAATCCGTA ACAGCAAAATCATTTTTACTTCAGCTTCTAAATGGCATAGCTTATTGCCATGATCGTCGT GTTTTACACAGAGATTTGAAGCCCCAGAATTTATTAATTAATAGAGAGGGAGAATTAAAA ATTGCCGACTTTGGGTTAGCCAGAGCATTTGGAATTCCTGTAAGAAAATATACGCATGAA GTAGTAACCTTATGGTATCGAGCACCAGATGTTTTAATGGGATCTAAGAAATATTCAACT ACTATTGATATATGGAGTGTTGGATGTATATTTGCTGAAATGGTAAATGGAACCCCATTA TTTCCAGGGGTATCTGAAGCAGACCAATTAATGAGGATATTTAGAATTCTAGGAACTCCT AATTCTAAAAATTGGCCAAATGTAACTGAACTACCAAAGTATGATCCTAATTTTACCGTA TATGAACCTTTACCATGGGAATCATTTTTGAAGGGATTAGATGAATCTGGTATCGATTTG CTTTCAAAAATGCTAAAGCTTGATCCAAACCAAAGAATAACAGCAAAACAAGCTCTAGAA CATGCGTATTTTAAAGAAAACAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q07785 UniProtKB Entry Name CDC2H_PLAFK GenBank Protein ID 9934 GenBank Gene ID X61921 PDB ID(s) 1LCH, 1OB3, 1V0B, 1V0O, 1V0P - General References
- Ross-Macdonald PB, Graeser R, Kappes B, Franklin R, Williamson DH: Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum. Eur J Biochem. 1994 Mar 15;220(3):693-701. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Indirubin-5-sulphonate experimental unknown target Details Purvalanol experimental unknown target Details