3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
Details
- Name
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- Kind
- protein
- Synonyms
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA
- 4.2.1.59
- Beta-hydroxydecanoyl thioester dehydrase
- Trans-2-decenoyl-[acyl-carrier-protein] isomerase
- Gene Name
- fabA
- UniProtKB Entry
- P0A6Q5Swiss-Prot
- Organism
- Shigella flexneri
- NCBI Taxonomy ID
- 623
- Amino acid sequence
>lcl|BSEQ0011309|3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELD INPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLP TAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF
- Number of residues
- 172
- Molecular Weight
- 18968.945
- Theoretical pI
- 6.52
- GO Classification
- Functions3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity / 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity / trans-2-decenoyl-acyl-carrier-protein isomerase activityProcessesfatty acid biosynthetic processComponentscytoplasm
- General Function
- Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).
- Specific Function
- (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
- Pfam Domain Function
- FabA (PF07977)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011310|3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (fabA) ATGGTAGATAAACGCGAATCCTATACAAAAGAAGACCTTCTTGCCTCTGGTCGCGGTGAA CTGTTTGGCGCTAAAGGCCCGCAATTGCCAGCACCGAACATGCTGATGATGGACCGTGTG GTCAAAATGACCGAAACGGGTGGTAACTTCGACAAAGGGTATGTTGAAGCAGAACTGGAT ATCAATCCGGATCTGTGGTTCTTCGGATGCCACTTTATTGGCGATCCGGTTATGCCGGGA TGCCTGGGCCTGGACGCAATGTGGCAGCTGGTAGGGTTCTACCTCGGCTGGCTGGGCGGC GAAGGTAAAGGCCGCGCGCTGGGCGTTGGCGAAGTGAAATTCACTGGTCAGGTACTGCCG ACAGCGAAAAAAGTGACCTACCGTATTCACTTTAAACGCATTGTTAACCGTCGTCTGATT ATGGGCCTGGCGGATGGCGAAGTGCTGGTTGATGGTCGTCTGATCTATACCGCCAGCGAC CTGAAAGTCGGTCTGTTCCAGGATACGTCTGCCTTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A6Q5 UniProtKB Entry Name FABA_SHIFL GenBank Protein ID 24051235 GenBank Gene ID AE005674 KEGG ID sfl:SF0954 NCBI Gene ID 1023905 - General References
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
- Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-Decenoyl N-acetyl cysteamine experimental unknown target Details